{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:13:38Z","timestamp":1787606018713,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Studies evaluating combined penetrating keratoplasty and pars plana vitrectomy for infectious aetiologies are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the outcomes of combined penetrating keratoplasty and pars plana vitrectomy in patients with endophthalmitis and poor corneal clarity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective interventional case series conducted at a tertiary care eye hospital in North India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Review of records of 43 eyes of 43 patients. Mean age of patients was 53.39 \u00b1 12.94 years (26 males). Patients with age &gt; 14 years with minimum follow\u2010up of 6 months were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Combined penetrating keratoplasty and pars plana vitrectomy was performed in all eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>We analysed the preoperative, intraoperative and microbiological characteristics of patients undergoing combined surgeries. Anatomic and functional success and failure were pre\u2010defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aetiology for corneal opacification was corneal ulcer in 30(69.7%) eyes, corneal graft infection in eight(18.6%) eyes, bullous keratopathy in four (9.3%) eyes and corneal scar in one eye. Postoperative visual acuity improved in 20(46.5%) eyes, did not change in 14 (32.5%) eyes and deteriorated in nine eyes (20.9%). Anatomical failure (uncontrolled infection leading to phthisis bulbi or evisceration) was seen in 15 (34.8%) eyes. Microbiological analysis revealed bacterial growth in 26, fungal in 14 and no growth in three eyes. Fungal infection had a poorer outcome (<jats:italic>P<\/jats:italic> = 0.03). Six out of 11 monoocular patients regained ambulatory vision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Combined penetrating keratoplasty and pars plana vitrectomy is a complex but globe salvaging procedure for poor prognosis eyes which otherwise may need evisceration. Fungal infection carries a poorer prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13370","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T04:31:34Z","timestamp":1533616294000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Outcomes of combined keratoplasty and pars plana vitrectomy for endophthalmitis with compromised corneal clarity"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-0709","authenticated-orcid":false,"given":"Abhishek","family":"Dave","sequence":"first","affiliation":[{"name":"Dr. Shroff's Charity Eye Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Acharaya","sequence":"additional","affiliation":[{"name":"Dr. Shroff's Charity Eye Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Dr. Shroff's Charity Eye Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi A","family":"Dave","sequence":"additional","affiliation":[{"name":"Dr. Shroff's Charity Eye Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Dr. Shroff's Charity Eye Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang","family":"Mathur","sequence":"additional","affiliation":[{"name":"Dr. Shroff's Charity Eye Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2732-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30415-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.834"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701794"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200302000-00007"},{"key":"e_1_2_6_7_1","first-page":"449","article-title":"Combined corneal allotransplantation and vitreoretinal surgery using an Eckardt temporary keratoprosthesis: analysis for factors determining corneal allograft survival","volume":"25","author":"Lee DS","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-002-0587-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200302000-00008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199909000-00010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.197"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305000"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00404-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90061-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.05.020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182883e9d"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318156caf2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01417.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.29074\/ascls.24.1.43","article-title":"Epidemiology and pathogenesis of Pseudomonas aeruginosa infections","volume":"24","author":"Moore NM","year":"2011","journal-title":"Clin Lab Sci"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198700710-00008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000025"}],"container-title":["Clinical &amp; 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