{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:26:43Z","timestamp":1785864403013,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Importance<\/jats:title><jats:p>There is a paucity of evidence analysing the treatment of cyclodialysis clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>We describe outcomes following the treatment of this rare condition at six centres internationally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Thirty\u2010six patients with a cyclodialysis cleft from 2003 to 2017 were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clefts were treated with cycloplegic agents, laser therapy and\/or surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Postoperative best recorded visual acuity (BRVA), intraocular pressure (IOP) and the rate of cleft closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 45\u2009\u00b1\u200917\u2009years and 29 (80.6%) patients were male. One eye (2.8%) received only medical therapy, 5 (13.9%) received laser, 14 (38.9%) underwent surgery after laser failure and 16 (44.4%) eyes received exclusively surgery. Over 80% of eyes had a BRVA improvement of more than two lines. Closure was attained in 30 eyes (93.8%; n\u2009=\u200932), with postoperative stabilized IOP\u2009\u2265\u200912\u2009mmHg in 29 eyes (80.6%; n\u2009=\u200936) and postoperative BRVA \u226420\/50 in 20 eyes (58.8%; n\u2009=\u200934). Improved postoperative BRVA was related to better preoperative BRVA (<jats:italic>P<\/jats:italic> =\u20090.006) and preoperative IOP\u2009\u2265\u20094\u2009mmHg (<jats:italic>P<\/jats:italic> =\u20090.03). There was no significant difference between treatment approach for IOP\u2009\u2265\u200912\u2009mmHg (<jats:italic>P<\/jats:italic> =\u20090.85) or postoperative BRVA \u226420\/50 (<jats:italic>P<\/jats:italic> =\u20090.80). Only two eyes at last follow\u2010up required IOP lowering medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>There was a high closure rate with most eyes eventually requiring surgery. Clinically significant improvements in BRVA were found in most eyes. Improved postoperative BRVA was significantly related to better preoperative BRVA and IOP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13378","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T04:19:39Z","timestamp":1534997979000},"page":"201-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cyclodialysis cleft repair: A multi\u2010centred, retrospective case series"],"prefix":"10.1111","volume":"47","author":[{"given":"Marko","family":"Popovic","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Shareef","sequence":"additional","affiliation":[{"name":"Flaum Eye Institute, University of Rochester School of Medicine and Dentistry  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mu\u00f1oz\u2010Negrete","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Razeghinejad","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Wills Eye Institute  Philadelphia Pennsylvania"},{"name":"Poostchi Eye Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal Ike K.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario 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