{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:21:17Z","timestamp":1783693277908,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2017R1D1A1B05028221"],"award-info":[{"award-number":["2017R1D1A1B05028221"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Importance<\/jats:title><jats:p>Analysing choroidal flow in central serous chorioretinopathy (CSC) with novel device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To examine the abnormal morphology of choriocapillary flow with optical coherence tomography angiography (OCTA) according to the presence of subretinal fluid (SRF) in CSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A hospital\u2010based retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>We analysed OCTA results of 68 eyes (68 patients) diagnosed as CSC with or without SRF (active and resolved CSC, respectively) at the Asan Medical Center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We classified OCTA choriocapillary images into three pattern groups: mixed perfusion, hyper\u2010perfusion and normal perfusion. Data analysis included age, follow\u2010up duration, treatment modalities, number of treatments, subfoveal choroidal thickness and SRF height.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The relationship between CSC activity and choriocapillary pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal choroidal flow (mixed and hyper\u2010perfusion) was more frequently found in eyes with active CSC (100%) than resolved CSC (47.5%, <jats:italic>P<\/jats:italic> &lt; 0.001). In active CSC eyes, mixed perfusion was predominant (71.4%), while hyper\u2010perfusion was predominant in those with resolved CSC (73.7%). Eyes with recently resolved CSC (SRF absorption present for &lt;2 months) had abnormal choriocapillary flow more often than the remaining eyes with resolved CSC (83.3% vs 32.1%, <jats:italic>P<\/jats:italic> =\u20090.005). Resolved CSC eyes with abnormal choriocapillary flow demonstrated more recurrence than eyes with normal choriocapillary flow (42.1% vs 9.5%, <jats:italic>P<\/jats:italic> =\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The pattern of choriocapillary flow abnormalities on OCTA can indicate CSC disease activity. Because eyes with resolved CSC showing abnormal choroidal flow have a high recurrence rate, they should be carefully followed\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13454","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T08:49:59Z","timestamp":1543999799000},"page":"505-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Abnormal choroidal flow on optical coherence tomography angiography in central serous chorioretinopathy"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6574-7744","authenticated-orcid":false,"given":"Eoi Jong","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Yonsei Plus Eye Center  Sungnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taewoong","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Pureun Eye Center  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hee","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center University of Ulsan, College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Pathogenesis of disciform detachment of the neuroepithelium","volume":"63","author":"Gass JD","year":"1967","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32810-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.11.815"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.130"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.11.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200011000-00008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70531-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199616030-00004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210901900415"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.08.026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.04.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200312000-00002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345495"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-012-0162-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000557"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.004710"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17140"},{"key":"e_1_2_8_19_1","first-page":"10","article-title":"Optical coherence tomography angiography in central serous chorioretinopathy","volume":"1","author":"Costanzo E","year":"2015","journal-title":"J Ophthalmol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.4.000051"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.004130"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225936"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199911000-00005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20160324-03"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448436"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000742"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17246"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000765"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20150101-04"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.58"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.011"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000511"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000309115"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.021"}],"container-title":["Clinical &amp; 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