{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:23:48Z","timestamp":1783092228537,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Contact lens microbial keratitis (CLMK) is the most common cause of microbial keratitis in our community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Define the trend in rate of CLMK and define patient demographics\/culture results that may have a predictive value in patients with CLMK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective review of clinical records of patients with MK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>All patients with positive corneal scraping between 1999 and 2015 at the Princess Alexandra Hospital, Brisbane, Queensland identified through local microbiology database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Trend in CLMK tested with chi\u2010squared test of peak 3 years vs other years and Poisson regression of interrupted time series. Patient characteristics predictive of CLMK were defined by creating a polynomial regression model by stepwise variable selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Yearly rate of CLMK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Records of 895 episodes of MK were included. The most common: risk factor was contact lens wear (324, 36.2%), isolated organism was <jats:styled-content style=\"fixed-case\"><jats:italic>Pseudomonas aeruginosa<\/jats:italic><\/jats:styled-content> (<jats:italic>P. aeruginosa<\/jats:italic> 181, 55.9%) and treatment was monotherapy with a fluoroquinolone 172, 53%). CLMK was most common between 2009 and 2011 (49.5% vs other years 32%, <jats:italic>P<\/jats:italic> &lt; 0.001). Poisson regression of the interrupted time series showed there was a significant decrease in the rate over time after 2010 (<jats:italic>P<\/jats:italic> &lt; 0.001). Independent factors predictive of CLMK in multivariate regression were young age (15\u201049\u2009years) and corneal culture positive for <jats:italic>P. aeruginosa<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The rate of CLMK in our community ranged between 32% and 50% and the rate of disease appears to have peaked during 2009 to 2011 and subsequently declined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13484","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T03:25:32Z","timestamp":1551151532000},"page":"726-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Trends in contact lens microbial keratitis 1999 to 2015: a retrospective clinical review"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-3741","authenticated-orcid":false,"given":"Matthew","family":"Green","sequence":"first","affiliation":[{"name":"Ophthalmology department Gold Coast University Hospital  Southport Queensland Australia"},{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Sara","sequence":"additional","affiliation":[{"name":"Ophthalmology department Sydney Eye Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hughes","sequence":"additional","affiliation":[{"name":"Ophthalmology department Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Apel","sequence":"additional","affiliation":[{"name":"Ophthalmology department Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Stapleton","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318156caf2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01511.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702953"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.04.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.08.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.9.1103"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1996.133"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/769436"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001905"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.250"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.01.052"},{"issue":"1","key":"e_1_2_6_13_1","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"46","author":"Bernal JL","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31823ee077"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2012.00773.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2010.00487.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312881"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01910.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.1718"}],"container-title":["Clinical &amp; 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