{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:50:44Z","timestamp":1747183844726,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Paediatric uveitis is a severe sight\u2010threatening uveitis due to disease progression and treatment failure. Biological agents are a promising new treatment. This study provides real\u2010world data on their use from Sydney, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Traditionally corticosteroids and non\u2010biological immunosuppressive agents were used to treat paediatric uveitis, often with poor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective, chart review over an 8\u2010year period at a tertiary referral eye hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 27 paediatric uveitis patients treated with biological agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chart review of demographic data and treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Treatment efficacy (corticosteroid\u2010sparing effect, topical steroid cessation\/reduction, reduction in systemic\u2010steroid sparing agents, change in intraocular inflammation, visual acuity and central macular thickness); treatment failure; and adverse events. Data were collected at biological initiation, 6 weeks, 6 months and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biological therapy over 1 year was effective with prednisolone dose reduced to &lt;5 mg\/day in five of six patients (83%), number of systemic steroid\u2010sparing agents was reduced to \u22641 in two of four patients (50%) and cessation of topical steroid achieved in 12\/41 of eyes (29%). Improvement of anterior chamber cells by two grades occurred in 20\/25 eyes (80%), improvement of logMAR to \u22640.3 occurred in 12\/18 eyes (67%) and macular oedema decreased in 4\/5 eyes (80%). Treatment failure occurred in six eyes (13.01%) and five patients (18.5%) developed an adverse reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Biological therapy was effective in paediatric patients with uveitis. Intraocular inflammation improved with maintained visual acuity, systemic corticosteroid dose decreased and there was a low frequency of adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13494","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T03:15:25Z","timestamp":1551755725000},"page":"741-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changing biological disease modifying treatment for paediatric uveitis in the real world"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-2148","authenticated-orcid":false,"given":"Lawrence J.","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Sydney Eye Hospital  Sydney Australia"},{"name":"Department of Ophthalmology, Paediatric Uveitis Study Group Save Sight Institute  Sydney Australia"},{"name":"Department of Ophthalmology Sydney University  Sydney 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