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The main aim of the treatment of uveitis is to control the inflammation, prevent recurrences of the disease and preserve vision while minimizing the adverse effects associated with the therapeutic agents. Initial management of uveitis relies heavily on the use of corticosteroids. However, monotherapy with high\u2010dose corticosteroids is associated with side effects and cannot be maintained long term. Therefore, steroid\u2010sparing agents are needed to decrease the burden of steroid therapy. Currently, the therapeutic approach for non\u2010infectious uveitis (NIU) consists of a step\u2010ladder strategy with the first\u2010line option being corticosteroids in various formulations followed by the use of first\u2010, second\u2010 and third\u2010line agents in cases with suboptimal steroid response. Unfortunately, the agents currently at our disposal have limitations such as having a narrow therapeutic window along with their own individual potential side\u2010effect profiles. Therefore, research has been targeted to identify newer drugs as well as new uses for older drugs that target specific pathways in the inflammatory response. Such efforts are made in order to provide targeted and safer therapy with reduced side effects and greater efficacy. Several specially designed molecular antibodies are currently in various phases of investigations that can potentially halt the inflammation in patients with NIU. In the review, we have provided a comprehensive overview of the current and upcoming therapeutic options for patients with NIU.<\/jats:p>","DOI":"10.1111\/ceo.13511","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T04:50:04Z","timestamp":1554180604000},"page":"396-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["New therapies in development for the management of non\u2010infectious uveitis: A review"],"prefix":"10.1111","volume":"47","author":[{"given":"Muhammad","family":"Hassan","sequence":"first","affiliation":[{"name":"Byers Eye Institute Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samendra","family":"Karkhur","sequence":"additional","affiliation":[{"name":"Byers Eye Institute Stanford University  Palo Alto California"},{"name":"Department of Ophthalmology Sadguru Netra Chikitsalaya  Chitrakoot 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