{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:50:47Z","timestamp":1747183847017,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Management of cystic bleb leak is difficult. It would be essential to look for a method to strengthen the original pathological conjunctiva and reverse bleb leak.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the long\u2010term efficacy and safety of collagen crosslinking in patients with leaking cystic bleb.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective interventional case series at a university\u2010based hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Twelve eyes in 12 subjects with late\u2010onset bleb leak from cystic bleb, without indications for prompt surgical interventions were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects underwent crosslinking with 0.1% riboflavin application to bleb surface, followed by ultraviolet irradiation for 30\u2009minutes. The subjects were followed up at baseline and at 1 week, 1 month, 3 months, 6 months post\u2010treatment and then every 6 months afterwards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Interval from treatment to cessation of bleb leak, recurrence rate of bleb leak and side effects of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up after crosslinking was 29.33\u2009\u00b1\u200912.45\u2009months. Bleb leak subsided in 11 (92%) of 12 patients after a single session of crosslinking, after 1 to 8 weeks (median 3 weeks). Time to leak cessation was significantly correlated with the number of prior glaucoma interventions (<jats:italic>R<\/jats:italic>\u2009=\u2009.71, <jats:italic>P<\/jats:italic>\u2009=\u2009.014). Bleb wall at 3 months was significantly thicker than at baseline (0.70\u2009\u00b1\u20090.67 vs 0.81\u2009\u00b1\u20090.62\u2009mm, <jats:italic>P<\/jats:italic>\u2009=\u2009.008). None of the patients experienced any complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Crosslinking achieves resolution of cystic bleb leak which lasts for at least 12\u2009months, without the need of subsequent surgical interventions. Crosslinking is a simple, non\u2010invasive treatment for bleb leak. It aims to restore the integrity of conjunctiva.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13520","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T14:35:51Z","timestamp":1556116551000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prospective study on a novel treatment for leaking cystic bleb: Efficacy and safety of collagen crosslinking"],"prefix":"10.1111","volume":"47","author":[{"given":"Yu","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, LKS Faculty of Medicine The University of Hong Kong  Hong Kong Hong Kong"},{"name":"Department of Ophthalmology Peking University First Hospital, Key Laboratory of Visual Impairment and Rehabilitation of Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-3935","authenticated-orcid":false,"given":"Bonnie N. K.","family":"Choy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LKS Faculty of Medicine The University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming M.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LKS Faculty of Medicine The University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai B.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Beijing Shijitan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C. H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LKS Faculty of Medicine The University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing L.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Grantham Hospital, Hong Kong West Cluster  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy S. M.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LKS Faculty of Medicine The University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,17]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/S0161-6420(86)33771-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1038\/eye.1995.107"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1001\/archopht.116.4.443"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1016\/S0039-6257(98)00025-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1016\/S0002-9394(14)71642-3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1016\/S0002-9394(14)73465-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1136\/bjo.75.3.170"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1016\/S0002-9394(14)70695-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1001\/archopht.1995.01100080102036"},{"key":"e_1_2_6_11_1","first-page":"210","article-title":"Management of chronic hypotony after glaucoma filtration surgery","volume":"5","author":"Liebmann JM","year":"1996","journal-title":"J Glaucoma"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1097\/IJG.0b013e3181e87efc"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1016\/S0161-6420(01)00838-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1016\/S0002-9394(14)71658-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1016\/S0161-6420(96)30701-X"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1136\/bjophthalmol-2012-302322"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1016\/j.ophtha.2013.01.012"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1016\/j.ophtha.2013.10.028"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1016\/j.jcrs.2011.11.029"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1007\/s00417-015-3245-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1097\/IJG.0000000000000295"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.1159\/000478051"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.17352\/2455-1414.000039"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1001\/archophthalmol.2009.161"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.1016\/S0161-6420(00)00282-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.5935\/0004-2749.20170008"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.13520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.13520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T16:37:26Z","timestamp":1694277446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.13520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,17]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/ceo.13520"],"URL":"https:\/\/doi.org\/10.1111\/ceo.13520","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"type":"print","value":"1442-6404"},{"type":"electronic","value":"1442-9071"}],"subject":[],"published":{"date-parts":[[2019,5,17]]},"assertion":[{"value":"2018-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}