{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:55:14Z","timestamp":1767898514146,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108008"],"award-info":[{"award-number":["81420108008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>The rate and determinants of persistence to topical glaucoma medications are important for identifying patients at high risk of discontinuing medications and designing targeted approaches to improve persistence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the rate and determinants of persistence to topical glaucoma medications among middle\u2010aged and older Australian adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Participants in need of persistent topical glaucoma medications in the 45 and Up Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 45 and Up Study is a large\u2010scale population\u2010based cohort study. Participants were classified as needing persistent topical glaucoma medications if at least three claims with related prescriptions were recorded. Persistence was defined as topical glaucoma medications were filled within 90\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The rates and determinants of medication persistence at 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12\u2009899 patients requiring persistent topical glaucoma medications were identified. Among them, 9019 (69.9%) had persisted with their glaucoma medications for at least 2 years. Multiple logistic regression analysis documented significant effects of patient\u2010related factors (gender, socioeconomic status, language spoken at home, lifestyle and comorbidities) and drug\u2010related factors (total number and drug class) on the persistence rate. Those most at risk groups of non\u2010persistence were those patients living in remote areas (odds ratio, OR: 0.59, 95% confidence interval, CI: 0.37\u20100.92), having family income over 70\u2009000 AUD\/year (OR: 0.53, 95% CI: 0.45\u20100.62), speaking other languages at home (OR: 0.61, 95% CI: 0.53\u20100.68), and using cholinergic classes of medications (OR: 0.55, 95% CI: 0.38\u20100.79).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Our data has shown a medium level of persistence to topical glaucoma medication among middle\u2010aged and older Australian adults. However, efforts are still needed to improve the rate of persistence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13524","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:59:05Z","timestamp":1556672345000},"page":"881-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Real\u2010world assessment of topical glaucoma medication persistence rates based on national pharmaceutical claim data in a defined population"],"prefix":"10.1111","volume":"47","author":[{"given":"Zhuoting","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 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