{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:06:46Z","timestamp":1790730406367,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Minimally invasive glaucoma surgery has gained significant traction in recent years. This study evaluates the first\u2010 and second\u2010generation trabecular micro\u2010bypass stents \u201ciStent\u201d and \u201ciStent <jats:italic>inject<\/jats:italic>\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate and compare the effect of a single iStent and double iStent <jats:italic>inject<\/jats:italic> in primary open angle glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective comparative case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Primary open angle glaucoma patients undergoing trabecular micro\u2010bypass stent insertion combined with cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline demographic information, preoperative, intraoperative and postoperative outcomes including intraocular pressure (IOP), visual acuity, reliance on glaucoma medication and complications were collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Primary, secondary and tertiary outcome measures were consecutively defined as an IOP of \u226418\u2009mmHg with zero medications, an IOP of \u226418\u2009mmHg with reduced medications or a 20% reduction in IOP with or without medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study comprised 145 eyes in the iStent and 100 eyes in the iStent <jats:italic>inject<\/jats:italic> group. At 12\u2009months, 56.0% of the iStent and 51.3% of the iStent <jats:italic>inject<\/jats:italic> eyes had achieved primary success and 63.1% and 57.7% secondary success. The mean postoperative IOP was 16.6 mmHg in iStent and 16.9 mmHg in iStent <jats:italic>inject<\/jats:italic>. Survival analysis demonstrated a greater incidence of failure in the iStent <jats:italic>inject<\/jats:italic> beyond 5 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Both trabecular micro\u2010bypass stents in this study were effective in reducing IOP and the burden of medication when combined with cataract surgery. There was no statistically significant difference between the two groups across our outcome measures although the iStent <jats:italic>inject<\/jats:italic> required earlier recommencement of medications for optimal IOP control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13526","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:52:46Z","timestamp":1556671966000},"page":"898-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Minimally invasive glaucoma surgery: Comparison of iStent with iStent <i>inject<\/i> in primary open angle glaucoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-364X","authenticated-orcid":false,"given":"Joobin","family":"Hooshmand","sequence":"first","affiliation":[{"name":"Tasmanian Eye Institute  Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-9270","authenticated-orcid":false,"given":"Philip","family":"Rothschild","sequence":"additional","affiliation":[{"name":"Tasmanian Eye Institute  Launceston Tasmania Australia"},{"name":"Clinical School University of Tasmania  Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"Allen","sequence":"additional","affiliation":[{"name":"Tasmanian Eye Institute  Launceston Tasmania Australia"},{"name":"Clinical School University of Tasmania  Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-285X","authenticated-orcid":false,"given":"Nathan M.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"Vote","sequence":"additional","affiliation":[{"name":"Tasmanian Eye Institute  Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze'Yo","family":"Toh","sequence":"additional","affiliation":[{"name":"Tasmanian Eye Institute  Launceston Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307994"},{"key":"e_1_2_6_3_1","unstructured":"NewmanA AndrewN.Changes in Australian practice patterns for glaucoma management since the introduction of Minimally Invasive Glaucoma Surgery (MIGS). In Melbourne Ophthalmic Alumni Meeting 12 May 2018 Melbourne Australia."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12888"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131770"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128146"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000457"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210901900311"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2016.06.017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2016.07.001"},{"key":"e_1_2_6_12_1","first-page":"321","article-title":"One\u2010year analysis of the iStent trabecular microbypass in secondary glaucoma","volume":"5","author":"Buchacra O","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.07.007"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.13526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.13526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T20:33:59Z","timestamp":1694205239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.13526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/ceo.13526"],"URL":"https:\/\/doi.org\/10.1111\/ceo.13526","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,16]]},"assertion":[{"value":"2018-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}