{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:36:59Z","timestamp":1792103819226,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["107310"],"award-info":[{"award-number":["107310"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["102367"],"award-info":[{"award-number":["102367"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>A new method to help diagnose suspected cyclodialysis clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To study the use of trypan blue stained aqueous flow patterns in diagnosing causes of hypotony where cyclodialysis clefts were suspected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A case series in a tertiary care centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Ten subjects presenting with persistent hypotony and retinal changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Trypan blue was injected into the anterior chamber.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>The pattern of dye flow in the anterior chamber was categorized. Intraocular pressure prior to surgery was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All seven subjects with cyclodialysis clefts had a preferential flow to the cleft region. Two hypotonous subjects post trabeculectomy had rapid (5 seconds) and extensive lymphatic staining (6\u2009o'clock hours extent) without visible bleb formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Preferential flow of dye to the limbus is a reliable sign of cyclodialysis cleft and helps localize cleft extent. A new cause of hypotony, \u201clymphatic overdrain,\u201d is identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13558","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T15:40:02Z","timestamp":1557934802000},"page":"904-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Use of trypan blue as an aqueous tracer dye to investigate hypotony where cyclodialysis cleft is suspected"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-6201","authenticated-orcid":false,"given":"Ying J.","family":"Khoo","sequence":"first","affiliation":[{"name":"Lions Eye Institute University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aulia A. H.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Brawijaya University Dr Saiful Anwar General Hospital  Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-534X","authenticated-orcid":false,"given":"Dao\u2010Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Lions Eye Institute University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-6922","authenticated-orcid":false,"given":"William H.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Lions Eye Institute University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)31021-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.06.004"},{"key":"e_1_2_6_4_1","first-page":"10","article-title":"Les Vaisseaux lymphatiques de la conjonctive bulbaire humaine etudies par la methode des injections vitales de bleutripan","volume":"8","author":"Busacca A","year":"1948","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3944"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.1989.3.2.65"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00660815"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702031"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.139"},{"key":"e_1_2_6_10_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.15761\/JTS.1000135"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.13558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T20:33:44Z","timestamp":1694205224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.13558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,30]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/ceo.13558"],"URL":"https:\/\/doi.org\/10.1111\/ceo.13558","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,30]]},"assertion":[{"value":"2018-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}