{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:54:54Z","timestamp":1766181294617,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>To evaluate the safety and efficacy of ab interno trabeculotomy (AIT) (trabecular ablation) with the trabectome in patients with uveitic glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Traditional glaucoma filtration surgeries in the uveitic patient population come with a higher risk of complications such as failure and hypotony.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective observational cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>All patients diagnosed with uveitic glaucoma were included in this study. Patients were excluded if they have less than 12\u2009months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who received AIT alone or combined with phacoemulsification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Major outcomes include intraocular pressure (IOP), number of glaucoma medications and secondary glaucoma surgery, if any. Kaplan\u2010Meier method was used for survival analysis and success was defined as IOP \u226421\u2009mmHg, at least 20% IOP reduction from baseline for any two consecutive visits after 3 months, no additional glaucoma medications, and no secondary glaucoma surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 eyes, 45 patients, with an average age of 52\u2009years were included in the study. The majority were Japanese (40%) and underwent AIT alone (71%). IOP was reduced from 29.2\u2009\u00b1\u20098.0 to 16.7\u2009\u00b1\u20094.6\u2009mmHg at 12\u2009months (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01*), while the number of glaucoma medications was reduced from 4.0\u2009\u00b1\u20091.0 to 2.5\u2009\u00b1\u20091.6 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01*). Survival rate at 12\u2009months was 91%. Six cases required secondary glaucoma surgery and no other serious complication were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>The trabectome AIT procedure appears to be effective in reducing IOP in uveitic glaucoma patients. Although no statistically significant difference was found in the number of glaucoma medications, a decreasing trend was found.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13639","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T16:09:40Z","timestamp":1568131780000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical results of ab interno trabeculotomy using the trabectome in patients with uveitic glaucoma"],"prefix":"10.1111","volume":"48","author":[{"given":"Ramya","family":"Swamy","sequence":"first","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"},{"name":"Department of Ophthalmology University of Maryland  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-7832","authenticated-orcid":false,"given":"Brian A.","family":"Francis","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Akil","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"},{"name":"Department of Visual Sciences University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-7690","authenticated-orcid":false,"given":"Aleksandr","family":"Yelenskiy","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon A.","family":"Francis","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Chopra","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-9608","authenticated-orcid":false,"given":"Alex","family":"Huang","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute and Stein Eye Institute, Department of Ophthalmology, Geffen School of Medicine University of California, Los Angeles (UCLA)  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.04.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/742792"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200404000-00003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200404000-00014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000071"},{"key":"e_1_2_6_7_1","first-page":"40","article-title":"Clinical results with the trabectome, a novel surgical device for treatment of open\u2010angle glaucoma","volume":"104","author":"Minckler D","year":"2006","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.03.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31171-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S72383"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-013-2888-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151947"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3102-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12796"}],"container-title":["Clinical &amp; 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