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This review aims to summarize and analyse all of the published data on CHRPE in patients with classic FAP and then ascertain whether these patients should undergo a relatively cheap and non\u2010invasive dilated fundus examination to screen for CHRPE. Adhering to Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines our database search identified 102 relevant articles of which 13 were selected for further analysis. The percentage of FAP patients with CHRPE was found to be 80.00%, whereas the percentage of at\u2010risk patients with CHRPE was 31.12%. Despite various statistically significant findings, CHRPE alone cannot be used as a surrogate for diagnosing FAP in those with a positive family history. The authors advocate a combined approach of eye examinations, colonoscopy and genetic testing.<\/jats:p>","DOI":"10.1111\/ceo.13643","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T20:26:01Z","timestamp":1568665561000},"page":"98-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["In patients with a positive family history of familial adenomatous polyposis can the condition be diagnosed from the presence of congenital hypertrophy of the retinal pigment epithelium detected via an eye examination: A systematic review"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9530-7245","authenticated-orcid":false,"given":"Shahzaib","family":"Rehan","sequence":"first","affiliation":[{"name":"Ophthalmology Department Royal Glamorgan Hospital  Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyaw","family":"Aye","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Royal Glamorgan Hospital  Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:INTE.0000031739.62559.ac"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00211023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-22"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-734"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"287","article-title":"The value of opthalmic examinations in familial adenomatous polyposis syndrome screening","volume":"16","author":"Katsanos KH","year":"2003","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199401000-00002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.5"},{"key":"e_1_2_7_9_1","unstructured":"The College of Optometrists. 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