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These tumours are challenging to treat, and today management generally involves a multispecialty team coordinating a treatment protocol that may include intraocular chemotherapy, ocular irradiation, systemic chemotherapy and\/or autologous stem cell transplantation. The ophthalmologist has specific responsibility for the intraocular chemotherapy, which is delivered to the eye by intravitreal injection. The most commonly injected drugs are methotrexate\u2014an anti\u2010metabolite\u2014and rituximab\u2014an anti\u2010human B cell monoclonal antibody. A range of intraocular chemotherapy treatment schedules have been described in the medical literature, although to date there have been no randomized clinical trials of these schedules. In this article, we review the development and current status of intraocular chemotherapy for vitreoretinal lymphoma.<\/jats:p>","DOI":"10.1111\/ceo.13668","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T01:43:56Z","timestamp":1572831836000},"page":"240-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Intraocular chemotherapy for vitreoretinal lymphoma: A review"],"prefix":"10.1111","volume":"48","author":[{"given":"Michael","family":"Kvopka","sequence":"first","affiliation":[{"name":"Flinders University College of Medicine and Public Health  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart R.","family":"Lake","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit \u2013 Division of Surgery, Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-5493","authenticated-orcid":false,"given":"Justine R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Flinders University College of Medicine and Public Health  Adelaide South Australia Australia"},{"name":"Ophthalmology Unit \u2013 Division of Surgery, Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0210"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000255"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-0890-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.569"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930801)72:3<843::AID-CNCR2820720333>3.0.CO;2-#"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13304"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.848905"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-018-0120-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.043"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2598"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14025"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-017-0067-x"},{"key":"e_1_2_11_14_1","first-page":"161","article-title":"Intravitreal chemotherapy for intraocular lymphomaunresponsive to conventional therapeutic modalities","volume":"102","author":"Smet MD","year":"1995","journal-title":"Ophthalmology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70444-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.4.448"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.7311"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.09.018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702804"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31804ac032"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304043"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.1810"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25350"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31820a67e4"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.099598"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02064.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000399"},{"key":"e_1_2_11_28_1","unstructured":"National Center for Biotechnology Information.Methotrexate.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/126941. 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