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There are only 20 studies on the eyelid effects of cannabis usage as a medical treatment or a recreational drug. These include ptosis induction, an \u201ceyelid tremor\u201d appearance and blepharospasm attenuation. Six articles describe how adequately dosed cannabis regimens could be promising medical treatments for blepharospasm induced by psychogenic factors. Fourteen articles report eyelid tremors in intoxicated drivers and ptosis as a secondary effect in cannabinoid animal experimental models. The exact mechanism of cannabinoids connecting cannabis to the eyelids is unclear. Further studies should be conducted to better understand the cannabinoid system in relation to the eyelid and eventually develop new, effective and safe therapeutic targets derived from cannabis.<\/jats:p>","DOI":"10.1111\/ceo.13687","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T16:04:33Z","timestamp":1574265873000},"page":"230-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between cannabis and the eyelids: A comprehensive review"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-946X","authenticated-orcid":false,"given":"Anne X.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Faculty of Medicine McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization [Internet]. 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