{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:08:22Z","timestamp":1779257302866,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Cataract and primary open\u2010angle glaucoma (POAG) commonly co\u2010exist, and cataract surgery is thought to reduce intraocular pressure (IOP), the major modifiable risk factor of POAG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies exploring the effect of cataract surgery on IOP are limited by retrospective design, lack of a control group, medication use and washout and loss to follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, multicentre, matched case\u2010control Australian study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>171 eyes of 108 POAG patients who underwent cataract surgery, matched to 171 control eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serial longitudinal IOP measurements were compared before and after cataract surgery, and relative to the controls. A mixed\u2010effect model was used for the longitudinal data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Change in IOP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up time was 4.8 (1.4) years. Cataract surgery reduced mean IOP by 2.22\u2009mmHg (95% confidence interval: 1.93\u20102.52\u2009mmHg, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) with 59 eyes (34%) achieving at least 3\u2009mmHg reduction. Compared to matched controls, the mean reduction in IOP was 1.75\u2009mmHg (95% confidence interval 1.15\u20102.33\u2009mmHg; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Higher preoperative IOP and being on fewer topical glaucoma medications preoperatively were strongly predictive of a larger IOP reduction in a multivariable model. Anterior chamber depth was not associated with IOP reduction. Eyes with preoperative IOP \u226524\u2009mmHg had a mean IOP reduction of 4.03\u2009mmHg with 81% experiencing at least 3\u2009mmHg reduction. Sub\u2010analysis of medication na\u00efve and pseudoexfoliation patients showed similar results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Cataract surgery has a confirmed effect in reducing IOP in a \u201creal world\u201d setting of early glaucoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13724","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T11:59:11Z","timestamp":1581076751000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: A prospective multi\u2010site study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-2941","authenticated-orcid":false,"given":"Ayub","family":"Qassim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Flinders University, 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