{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:25:31Z","timestamp":1787635531568,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009317","name":"Faculty of Health and Medical Sciences, University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001108","name":"Ophthalmic Research Institute of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Atropine eyedrops are a promising treatment for slowing myopia progression in East Asian children. However, its effects on children in Australia, including those of non\u2010Asian background, have not been well\u2010studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Western Australia Atropine for the Treatment of Myopia (WA\u2010ATOM) study aims to determine the efficacy and long\u2010term effects of low\u2010dose atropine eyedrops in myopia control. This paper describes the study rationale, methodology and participant baseline characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Single\u2010centre, double\u2010masked, randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Children (6\u201016\u2009years) with spherical equivalent \u2264\u22121.50\u2009D in each eye, astigmatism \u22641.50\u2009D and myopia progression by \u22650.50\u2009D\/year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Enrolled children were randomly assigned 2:1 to receive 0.01% atropine or placebo eyedrops. Participants are examined every 6\u2009months during first 3\u2009years of the study (2\u2010year treatment phase followed by a 1\u2010year washout phase), and then at a 5\u2010year follow\u2010up (2\u2009years after the end of the washout phase).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Annual progression rate of myopia and axial length, tolerability to eyedrops and incidence and severity of unwanted effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 311 children who were referred, 242 were suitable for study participation, and 153 were subsequently enrolled. The baseline characteristics of enrolled participants are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Outcomes of the WA\u2010ATOM study will inform on the efficacy, tolerability, safety and long\u2010term effects of low\u2010dose atropine eyedrops in myopia control in Australian children. The impact of ocular sun exposure, iris colour and parental myopia on the efficacy of low\u2010dose atropine will also be assessed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.13736","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T08:16:00Z","timestamp":1582704960000},"page":"569-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Western Australia Atropine for the Treatment of Myopia (WA\u2010ATOM) study: Rationale, methodology and participant baseline characteristics"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6635-1098","authenticated-orcid":false,"given":"Samantha S.Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Centre for Ophthalmology and Visual Sciences (incorporating Lions Eye Institute) University of Western Australia  Perth Western Australia 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