{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:14:47Z","timestamp":1792671287750,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Long\u2010term data of intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to assess visual and anatomic outcomes of eyes with neovascular age\u2010related macular degeneration (nAMD) after 10\u2009years of anti\u2010VEGF therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective analysis of data from a prospectively designed database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>One hundred and sixteen eyes with nAMD (94 participants) that started anti\u2010VEGF therapy at least 10\u2009years earlier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eyes were tracked by the Fight Retinal Blindness! registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Mean change in visual acuity at 10\u2009years vs baseline. Visual acuity was assessed by the number of letters read on a logarithm of the minimum angle of resolution chart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eyes received a median of 27.5 injections over 10\u2009years. Mean visual acuity was 57.5 letters (SD 17.5) at baseline. It increased slightly at 1\u2009year, then dropped steadily by 18 letters (95% CI: 13.7; 22.3) at 10\u2009years. Overall, 10% of eyes gained \u226510 letters, 64% lost \u226510 letters and 23% remained stable (\u00b15 letters from baseline). Geographic atrophy and subretinal fibrosis were found in 93% and 71%, respectively, after 10\u2009years, both mostly affecting the centre of the fovea. Pre\u2010treated eyes (47.5%) had significantly worse visual acuity than treatment\u2010na\u00efve eyes at baseline and during follow\u2010up and were significantly more likely to have atrophy and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Despite short\u2010term stabilization, long\u2010term visual outcomes of nAMD eyes under anti\u2010VEGF therapy may be poor. Development of atrophy and fibrosis, resulting from the natural progression of the disease, may partly explain this evolution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.13742","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:00:32Z","timestamp":1582970432000},"page":"636-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Ten\u2010year outcomes of anti\u2010vascular endothelial growth factor treatment for neovascular age\u2010related macular disease: A single\u2010centre French study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4709-692X","authenticated-orcid":false,"given":"Benjamin","family":"Wolff","sequence":"first","affiliation":[{"name":"Maison Rouge Ophthalmologic Centre  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Macioce","sequence":"additional","affiliation":[{"name":"Clinical Research and Epidemiology Unit CHU Montpellier, University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Vasseur","sequence":"additional","affiliation":[{"name":"Maison Rouge Ophthalmologic Centre  Strasbourg France"},{"name":"Research Department Rothschild Foundation  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Castelnovo","sequence":"additional","affiliation":[{"name":"Maison Rouge Ophthalmologic Centre  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Michel","sequence":"additional","affiliation":[{"name":"Maison Rouge Ophthalmologic Centre  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-9803","authenticated-orcid":false,"given":"Vuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"The Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5675-0861","authenticated-orcid":false,"given":"Vincent","family":"Daien","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Gui de Chauliac Hospital  Montpellier France"},{"name":"Inserm, U1061  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Mauget\u2010Fa\u00ffsse","sequence":"additional","affiliation":[{"name":"Research Department Rothschild Foundation  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gillies","sequence":"additional","affiliation":[{"name":"The Save Sight Institute, Sydney Medical School The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31550-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00736.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.02.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.03.046"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13522"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001282"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318296b271"},{"key":"e_1_2_6_11_1","unstructured":"International Council of Ophtalmology. 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