{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:23:14Z","timestamp":1762431794400,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>This study reports outcomes of myopic photorefractive keratectomy (PRK) in a mainly ethnic Chinese population in Singapore.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the incidence and associations of corneal haze and endothelial cell count (ECC) loss up to 12\u2009months after PRK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a retrospective case series conducted in a tertiary eye centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 158 patients (309 eyes) with a mean age of 22.1\u2009\u00b1\u20093.4\u2009years were included. The majority was Chinese (97.4%) and male (97.4%). Mean preoperative spherical equivalent was \u22123.33\u2009\u00b1\u20091.15\u2009D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eyes were categorized based on postoperative haze severity. A multivariate analysis adjusting for age and use of intraoperative mitomycin\u2010C (MMC), preoperative sphere and cylinder was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Refractive outcomes and corneal haze 3 and 12\u2009months after PRK were assessed. ECC measurements were obtained before PRK and at variable periods postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12\u2009months, overall efficacy index was 0.98, and safety index was 1.09. Eight (2.5%) eyes underwent enhancement surgery. An analysis was performed on 295 eyes that did not undergo enhancement and had complete clinical data, which demonstrated a decrease in the incidence of haze from 38.2% at 3\u2009months to 9.3% at 12\u2009months. Higher myopia was associated with increased haze severity at 3\u2009months (OR, 1.36; <jats:italic>P<\/jats:italic> =\u2009.005). Higher astigmatism was associated with increased haze severity at 3 (OR, 1.65; <jats:italic>P<\/jats:italic> =\u2009.018) and 12\u2009months (OR, 2.32; <jats:italic>P<\/jats:italic> =\u2009.015). Intraoperative MMC was not associated with haze severity or ECC loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and relevance<\/jats:title><jats:p>Myopia and astigmatism were associated with increased corneal haze severity. Intraoperative MMC did not accelerate ECC loss. Overall, PRK is effective, predictable and safe in Asian eyes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13759","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T18:09:46Z","timestamp":1587492586000},"page":"558-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Refractive outcomes, corneal haze and endothelial cell loss after myopic photorefractive keratectomy in an Asian population: The Singapore Armed Forces' experience"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-4894","authenticated-orcid":false,"given":"Bryan Chin Hou","family":"Ang","sequence":"first","affiliation":[{"name":"Vision Performance Centre Military Medicine Institute, Singapore Armed Forces  Singapore Singapore"},{"name":"National Healthcare Group Eye Institute Tan Tock Seng Hospital  Singapore 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