{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:03:15Z","timestamp":1775142195572,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009396","name":"Universit\u00e4tsSpital Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015291","name":"Royal Free London NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Evaluating the treatment outcomes of diabetic macular oedema (DMO) in routine clinical practice provides data for comparison with those of clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Phase 3 clinical trials of vascular endothelial growth factor (VEGF) inhibitors for DMO have reported significant improvements in visual acuity (VA) not previously reported with laser and steroid treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective analysis of observational data from routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Eyes receiving treatments for DMO tracked in the Fight Retinal Blindness! Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 510 eyes (347 patients) that started DMO treatment between 2009 and 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Changes in DMO treatment patterns and mean change in VA (letters logMAR) and central subfield thickness (CST) 5\u2009years after starting treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment choice for DMO changed to predominantly VEGF inhibitors from 2009 to 2014. A total of 238 eyes (47%) were followed for at least 5\u2009years. The mean VA at the start of treatment improved from 2009 (58 letters) to 2014 (68 letters) while mean VA change at 5\u2009years were\u2009+\u20094.5 and\u2009+\u20095.3 letters for eyes starting treatment in 2009 and 2014, respectively. The mean CST dropped from 401\u2009\u03bcm at baseline to 314\u2009\u03bcm at 5\u2009years. Eyes received a median of four injections in the first, two in the second, third and fourth and three in the fifth years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Changing the treatment of DMO from macular laser and intravitreal triamcinolone to VEGF inhibitors from 2011 onwards was associated with better VA outcomes, part of which were due to better VA at the start of treatment. The outcomes of treatment in eyes in real\u2010world practice were, however, worse than those reported by clinical trials, likely because they were undertreated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13781","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T11:39:29Z","timestamp":1588937969000},"page":"802-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Changes in real\u2010world treatment patterns for diabetic macular oedema from 2009 to 2019 and 5\u2010year outcomes: Data from the Fight Retinal Blindness! Registry"],"prefix":"10.1111","volume":"48","author":[{"given":"Anne C.","family":"Biechl","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-4274","authenticated-orcid":false,"given":"Sanjeeb","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-9803","authenticated-orcid":false,"given":"Vuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Marsden Eye Specialists  Parramatta New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Young","sequence":"additional","affiliation":[{"name":"Gladesville Eye Specialists  Gladesville New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Fraser\u2010Bell","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemal","family":"Mehta","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute The University of Sydney  Sydney New South Wales Australia"},{"name":"Ophthalmology Department Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gillies","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Barthelmes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Zurich  Zurich Switzerland"},{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050120030015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.039"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.045"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.031"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.02.065"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14236\/jhi.v22i3.177"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318296b271"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-3794(99)00028-1"},{"key":"e_1_2_8_11_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Foundation for Statistical Computing","year":"2010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.393"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.12.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414264"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.02.022"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.07.032"},{"key":"e_1_2_8_19_1","unstructured":"U.S. Food and Drug Administration. Centre for Drug Evaluation and Research. Lucentis (Ranibizumab Injection). BLA 25156. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/125156s0069s0076lbl.pdf. Accessed April 20 2020."},{"key":"e_1_2_8_20_1","unstructured":"Administration USFaD. Centre for Drug Evaluation and Research. OZURDEX\u00ae (Dexamethasone Intravitreal Implant).https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/022315s009lbl.pdf. Accessed April 20 2020."},{"key":"e_1_2_8_21_1","unstructured":"Administration USFaD. Centre for Drug Evaluation and Research. EYLEA\u00ae (aflibercept) Injection for Intravitreal Use. BLA 125387.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2019\/125387s061lbl.pdf. Accessed April 20 2020."},{"key":"e_1_2_8_22_1","unstructured":"Australian Government Department of Health Therapeutic Goods Administration. Australian Public Assessment Report for Ranibizumab.2014.https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-ranibizumab-141014.doc. Accessed April 20 2020."},{"key":"e_1_2_8_23_1","unstructured":"Australian Government Department of Health Therapeutic Goods Administration. Australian Public Assessment Report for Aflibercept.2015.https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-aflibercept-150721.pdf. Accessed 20 April 2020."},{"key":"e_1_2_8_24_1","unstructured":"Australian Government Department of Health Therapeutic Goods Administration. Australian Public Assessment Report for Dexamethasone. 2016.https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-dexamethasone-161025.pdf. Accessed April 20 2020."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.010"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080110085041"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.05.037"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15217"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31193-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307950"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.04.010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.06.004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001892"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fceo.13781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.13781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:52:25Z","timestamp":1693936345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.13781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/ceo.13781"],"URL":"https:\/\/doi.org\/10.1111\/ceo.13781","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"assertion":[{"value":"2020-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}