{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:11:28Z","timestamp":1789683088653,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011905","name":"Evald and Hilda Nissi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Posterior capsular opacification (PCO) is the most common complication after cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to assess the relationship between intraocular lens (IOL) diopter and formation of PCO among a consecutive real\u2010world registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Included were 14\u2009264 consecutive cases of uncomplicated cataract surgery performed during 2014 to 2018 in Helsinki University Hospital in Finland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nd:YAG capsulotomies were used as an estimate of clinically significant PCO. A single eye of each patient and a single type of IOL were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Nd:YAG posterior capsulotomy free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 73.2 \u00b1\u20099.9\u2009years and 61.8% were female. Mean follow\u2010up time was 25.4 \u00b1\u200916.8 months. Overall PCO rates were 1.1% at 1\u2010year, 3.0% at 2\u2010year, 7.1% at 3\u2010year and 10.2% at 4\u2010year. Patients with IOL diopters (D) in the lower quartile (\u226420.0 D) had significantly higher rates of PCO (1.3% at 1\u2010year, 4.4% at 2\u2010years, 9.4% at 3\u2010years and 14.2% at 4\u2010years, <jats:italic>P<\/jats:italic> &lt;\u2009.001). A logistic regression model showed increased risk for PCO formation with lower diopter IOLs; for \u226420.0 D: OR 1.343 (95% CI: 1.132\u20101.593), for \u226410.0 D: OR 2.409 (95% CI 1.203\u20104.287), <jats:italic>P<\/jats:italic> &lt;\u2009.001 for all comparisons. In a multivariant regression accounting for possible confounders, results remained consistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Among a cohort of patients undergoing cataract surgery, use of lower diopter IOLs was associated with increased incidence of clinically significant PCO. Research into IOL biomechanics to decrease PCO may be warranted especially in lower diopter IOLs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13821","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T09:11:05Z","timestamp":1594199465000},"page":"889-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between intraocular lens diopter and posterior capsular opacification"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-0432","authenticated-orcid":false,"given":"Idan","family":"Hecht","sequence":"first","affiliation":[{"name":"Helsinki Retina Research Group University of Helsinki  Helsinki Finland"},{"name":"Department of Ophthalmology, Shamir Medical Center and Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biana","family":"Dubinsky\u2010Pertzov","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shamir Medical Center and Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petteri","family":"Karesvuo","sequence":"additional","affiliation":[{"name":"Helsinki Retina Research Group University of Helsinki  Helsinki Finland"},{"name":"Department of Ophthalmology Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-6908","authenticated-orcid":false,"given":"Asaf","family":"Achiron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wolfson Medical Center, Holon and Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1550-8125","authenticated-orcid":false,"given":"Raimo","family":"Tuuminen","sequence":"additional","affiliation":[{"name":"Helsinki Retina Research Group University of Helsinki  Helsinki Finland"},{"name":"Eye Centre Kymenlaakso Central Hospital  Kotka Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2019.03.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.05.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.01.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10389-017-0851-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S4890"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.045"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.1.21"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.08.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.01.017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2019.1645183"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00353-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.04.039"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.08.032"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00352-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(13)80278-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.08.028"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00204-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00354-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(98)80300-3"}],"container-title":["Clinical &amp; 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