{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:12Z","timestamp":1747183872669,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>To evaluate the natural history and outcomes of infants with stage\u20103 retinopathy of prematurity (ROP) persisting beyond 40\u2010weeks of post\u2010menstrual age <jats:bold>(<\/jats:bold>PMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>There are no specific screening guidelines for stage\u20103 ROP persisting beyond 40\u2009weeks of PMA. Persistent stage\u20103 disease in zone II without plus disease or in zone III with or without plus disease poses a dilemma for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participant<\/jats:title><jats:p>Neonates with stage\u20103 ROP persisting beyond 40\u2010weeks of PMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic data and ROP parameters were collected. Univariate\/multivariate analyses were utilized to assess risk factors associated with requiring treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Evaluating the structural outcomes for infants with stage\u20103 ROP persisting beyond 40\u2009weeks of PMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 2356 screened infants, 115 infants (4.9%, 172 eyes) met inclusion criteria. In 95 infants (139 eyes, 80.8%), ROP resolved spontaneously. Twenty\u2010one infants (33 eyes, 19.2%) were treated with laser\u2010photocoagulation; 16 eyes had reached type 1 ROP and 17 eyes had non\u2010type 1 ROP. No eye had unfavourable structural outcome. On multiple regression, non\u2010type 1 ROP with \u22652 continuous clock hours of persistent stage\u20103 temporally crossing the horizontal midline was a significant risk factor associated with receiving treatment (OR = 27.29, 95% CI = [1.61, 462.92], <jats:italic>P<\/jats:italic> = .0221).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Relevance<\/jats:title><jats:p>The majority of stage\u20103 ROP persisting beyond 40\u2010weeks of PMA resolve spontaneously. In eyes that do not reach type 1 ROP, \u22652 continuous clock hours of persistent stage\u20103 crossing the temporal horizontal midline and history of pre\u2010plus were considered important risk factors for macular drag and treatment can be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13827","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T10:15:25Z","timestamp":1594289725000},"page":"956-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Natural history and outcomes of stage 3 retinopathy of prematurity persisting beyond 40\u2009weeks of post\u2010menstrual age: Dilemma for treatment and follow up"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6156-6660","authenticated-orcid":false,"given":"Robert","family":"Koucheki","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maram","family":"Isaac","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasrin","family":"N Tehrani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamiar","family":"Mireskandari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.11.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2584"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007374"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.12.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31344-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.12.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31820d3f70"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3061"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2996"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.645"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32074-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.11.1470"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/21.2.101"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.128"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820530802506045"},{"key":"e_1_2_7_18_1","doi-asserted-by":"crossref","unstructured":"AdamsGG BunceC. 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