{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:30:37Z","timestamp":1783175437184,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>To analyse the preoperative conjunctival thickness in glaucomatous patients undergoing filtration surgery (FS), using optical coherence tomography (OCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The conjunctival status represents one of the most critical determinants of the FS outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Sixty\u2010seven patients candidate to FS for uncontrolled glaucoma were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>OCT was performed at the superior bulbar conjunctiva before FS, and at bleb site at the last follow\u2010up (LF\u2010up) after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Preoperative full, epithelial, and stromal conjunctival thickness (FCT, CET, CST) and reflectivity (CR), and LF\u2010up bleb\u2010wall thickness (BT), reflectivity (BR) and intraocular pressure (IOP), were the major outcomes. The relations between preoperative parameters and LF\u2010up\u2010IOP, BT and BR were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FS was completely successful in 23 patients (group 1), successful with medications in 22 (group 2), and failed in 22 (group 3). FCT, CET and CST were lower, whereas CR higher, in group 3 compared to groups 1 and 2 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05); BT was lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), whereas BR higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) in group 3 compared to group 1. FCT and CST were predictors of FS outcome with lower thickness associated with increased odds of failure (odds ratio 0.922, <jats:italic>P<\/jats:italic> = .08; 0.941, <jats:italic>P<\/jats:italic> = .025). LF\u2010up\u2010IOP inversely correlated with FCT and CST (<jats:italic>r<\/jats:italic> = \u22120.447, <jats:italic>P<\/jats:italic> = .003; <jats:italic>r<\/jats:italic> = \u22120.408, <jats:italic>P<\/jats:italic> = .007), whereas positively correlated with CR (<jats:italic>r<\/jats:italic> = 0.789, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>Preoperative conjunctival thickness and reflectivity show significant correlations with the FS outcome, both in terms of IOP and bleb\u2010wall features. Therefore, they may be proposed as predictive imaging biomarkers to estimate the risk of filtration failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13857","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T03:03:54Z","timestamp":1600398234000},"page":"1192-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Conjunctival thickness as a predictive imaging biomarker for the glaucoma filtration surgery outcome: An optical coherence tomography study"],"prefix":"10.1111","volume":"48","author":[{"given":"Leonardo","family":"Mastropasqua","sequence":"first","affiliation":[{"name":"Ophthalmology Clinic, Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Brescia","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione G.B. Bietti  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Sacchi","sequence":"additional","affiliation":[{"name":"University Eye Clinic, San Giuseppe Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Aloia","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Totta","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Scatena","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-6305","authenticated-orcid":false,"given":"Luca","family":"Agnifili","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department of Medicine and Aging Science University G. d'Annunzio of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.024"},{"key":"e_1_2_7_3_1","first-page":"2898","article-title":"In vivo goblet cell density as a potential indicator of glaucoma filtration surgery outcome","volume":"57","author":"Agnifili L","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47823-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.10.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.06.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17455"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090230060021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7988"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21795"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.094912"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181d9ccb0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.064"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2018.0124"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7749"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11003"},{"key":"e_1_2_7_17_1","first-page":"52","volume-title":"Clinical Decisions in Glaucoma","author":"Hodapp E","year":"1993"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.04.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15890"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0902"},{"key":"e_1_2_7_21_1","first-page":"679","article-title":"Effect of latanoprost and timolol on the histopathology of the rabbit conjunctiva","volume":"42","author":"Mietz H","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00166608"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32888-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027457"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182000"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.140186"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000388"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2019.10.002"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/610623"}],"container-title":["Clinical &amp; 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