{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:19Z","timestamp":1747183879135,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The main objective was to describe metastatic and survival rates in patients with small choroidal melanocytic lesions initially managed by observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, observational study of consecutive cases recruited from 2001 through 2018, followed for a median (mean, range) of 81.0 (89.3, 10\u2010204) months in a tertiary referral centre for ocular oncology. Seventy\u2010five consecutive patients diagnosed with small choroidal melanocytic lesions with risk factors for growth initially observed and who showed progression during follow\u2010up. Treatment was performed (plaque radiotherapy or enucleation in 96% and 4% of cases, respectively) at detection of tumour growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median (mean, range) tumour thickness was 2.2 (2.23, 1.08\u20103.40) mm, and median maximum basal diameter was 8.5 (8.16, 4\u201012) mm. At diagnosis, a median (mean, range) of 5 (5.48, 1\u20108) risk factors for progression were present. Lesions grew at a median (mean, range) rate of 0.42\u2009mm\/y (1.12, 0\u20107.68) in thickness and 1.05\u2009mm\/y (3.14, 0\u20104.8) in maximum diameter. Median (mean, range) time until growth was 17.00 (32.6, 1\u2010161) months post\u2010diagnosis, at which time tumours were treated. Five patients developed local recurrence after brachytherapy requiring enucleation. Four patients developed hepatic metastasis. Melanoma\u2010specific survival was 98% at 5\u2009years (95% CI, 94.2\u2010100%) and 91.6% (95% CI, 82\u2010100%) at 10 and 15\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In small melanocytic lesions with risk factors for growth, initial observation until detection of tumour growth results in a seemingly low risk of metastasis, suggesting that this may be an initial approach to consider in tumours with indeterminate malignant potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.13911","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:24:30Z","timestamp":1614342270000},"page":"251-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Survival in small choroidal melanocytic lesions with risk factors managed by initial observation until detection of tumour growth"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9322-6313","authenticated-orcid":false,"given":"Laura","family":"Vigu\u00e9s\u2010Jorba","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service Bellvitge University Hospital, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-6412","authenticated-orcid":false,"given":"Rahul","family":"Morwani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service Bellvitge University Hospital, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-7257","authenticated-orcid":false,"given":"Daniel","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service Bellvitge University Hospital, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-0295","authenticated-orcid":false,"given":"Maria C.","family":"Baradad\u2010Jurjo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service Bellvitge University Hospital, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-5576","authenticated-orcid":false,"given":"Luis","family":"Arias","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service Bellvitge University Hospital, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-1724","authenticated-orcid":false,"given":"Josep M.","family":"Piulats","sequence":"additional","affiliation":[{"name":"Department of Oncology Catalan Institute of Oncology, Avinguda de la Gran V\u00eda de l'Hospitalet, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-772X","authenticated-orcid":false,"given":"Cristina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Brachytherapy Catalan Institute of Oncology, Avinguda de la Gran V\u00eda de l'Hospitalet, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-1313","authenticated-orcid":false,"given":"Estefania","family":"Cobos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service Bellvitge University Hospital, L'Hospitalet de Llobregat  Barcelona 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