{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:32:02Z","timestamp":1792279922172,"version":"4.4.0"},"reference-count":181,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011408","name":"University of South Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000310","name":"Retina UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["099173\/Z\/12\/Z"],"award-info":[{"award-number":["099173\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004117","name":"A.G. Leventis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005302","name":"Alexander S. Onassis Public Benefit Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012618","name":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders characterised by photoreceptor degeneration or dysfunction. These disorders typically present with severe vision loss that can be progressive, with disease onset ranging from congenital to late adulthood. The advances in genetics, retinal imaging and molecular biology, have conspired to create the ideal environment for establishing treatments for IRDs, with the first approved gene therapy and the commencement of multiple clinical trials. The scope of this review is to familiarise clinicians and scientists with the current management and the prospects for novel therapies for: (1) macular dystrophies, (2) cone and cone\u2010rod dystrophies, (3) cone dysfunction syndromes, (4) Leber congenital amaurosis, (5) rod\u2010cone dystrophies, (6) rod dysfunction syndromes and (7) chorioretinal dystrophies. We also briefly summarise the investigated end points for the ongoing trials.<\/jats:p>","DOI":"10.1111\/ceo.13917","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T21:28:51Z","timestamp":1615238931000},"page":"270-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["Inherited retinal diseases: Therapeutics, clinical trials and end points\u2014A review"],"prefix":"10.1111","volume":"49","author":[{"given":"Michalis","family":"Georgiou","sequence":"first","affiliation":[{"name":"UCL Institute of Ophthalmology University College London  London UK"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Fujinami","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology University College London  London UK"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"Laboratory of Visual Physiology, Division of Vision Research National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center  Tokyo Japan"},{"name":"Department of Ophthalmology Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Michaelides","sequence":"additional","affiliation":[{"name":"UCL Institute of Ophthalmology University College London  London UK"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306505"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.02.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.04.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.298"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414221"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/aes-20-81"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315086"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-313278"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309975"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.9.641"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optm.2006.07.012"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2838"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-308823"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.02.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3619-8"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci34316"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64833"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.5.5.10"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61376-3"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.04.037"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000001357"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075666"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/hgtb.2018.267"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.10.006"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720662115"},{"key":"e_1_2_12_28_1","first-page":"953","volume-title":"Ryan's Retina","author":"Schachat AP","year":"2018"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.46.11.678"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000237081.80600.51"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000001379"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24565"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci81380"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2014.31"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.12.008"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0995-27"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15733"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710430114"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2017.1418389"},{"key":"e_1_2_12_40_1","volume-title":"GeneReviews(R)","author":"Kohl S","year":"1993"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201269"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.03.053"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1086\/341835"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq517"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.3.40"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27047"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27761"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20427"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25452"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq136"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.50"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14860"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.149"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00292"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035250"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20986"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1596"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci123980"},{"key":"e_1_2_12_59_1","first-page":"15","article-title":"Blue cone monochromacy: causative mutations and associated phenotypes","volume":"876","author":"Gardner JC","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06982-7"},{"key":"e_1_2_12_61_1","first-page":"24","article-title":"Human L\u2010 and M\u2010opsins restore M\u2010cone function in a mouse model for human blue cone monochromacy","volume":"17","author":"Deng WT","year":"2018","journal-title":"Mol Vis"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.02.021"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1988.tb04039.x"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1990.tb03582.x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.6.897"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.11.022"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2020.1766087"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.115"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112758108"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.21.2353"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017392"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47393-0"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.122"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21055"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13682"},{"key":"e_1_2_12_76_1","volume-title":"GeneReviews\u00ae[Internet]","author":"Kumaran NPM","year":"2018"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.193"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.1133"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017376"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.08.012"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12104"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130110497"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0746"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300457200"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20461"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1482"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1789-3"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2014.09.001"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-123072"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.12.031"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46285"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.76.6.375"},{"issue":"12","key":"e_1_2_12_93_1","first-page":"3925","article-title":"A high association with cone dystrophy in Fundus albipunctatus caused by mutations of the RDH5 gene","volume":"41","author":"Nakamura M","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024498826904"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)69740-7"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-311964"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309376"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15995"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315152"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.03.005"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307698"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/mop.0000000000000690"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.03.021"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6479"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci132990"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1525-0016(03)00144-8"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221364198"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.100827"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094272"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1089\/hgtb.2013.212"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.05.024"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0696-649"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.37"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1622"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.6367"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2017.12.001"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.08.004"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2015.93"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118847109"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509914112"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2015.035"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.05.005"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.297"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-257915"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx143"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv354"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.05.007"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu509"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1629"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.07.008"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022533099"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-020-0134-z"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10040278"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.11.042"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1086\/383228"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-020-0159-3"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717338115"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.10.019"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.12.013"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3734"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamaophthalmol.354"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.47"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.06.017"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy024"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74516-9"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.11.019"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0874"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)62117-0"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1509501"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.06.011"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.09.012"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/28\/8\/n02"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21454"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.7.6.10"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23739"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.11.38"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.4.2.14"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.10.5"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21935"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.6.4.18"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.10.003"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0502"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.8.2.1"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73645-5"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25880"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19313"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.11.008"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.04.026"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000001871"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.05.002"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-007-9087-4"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.124008"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16638-0_10"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311328"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2020.1737138"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7762"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.017"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.42"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21868"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6257(01)00194-1"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.1032"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.09.002"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.13917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.13917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T23:02:21Z","timestamp":1692399741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.13917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,20]]},"references-count":181,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/ceo.13917"],"URL":"https:\/\/doi.org\/10.1111\/ceo.13917","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,20]]},"assertion":[{"value":"2020-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}