{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:46:44Z","timestamp":1787161604020,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001518","name":"Maurice and Phyllis Paykel Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001518","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have evaluated corneal crosslinking (CXL) in a prospective, randomised fashion. This study aimed to determine the efficacy and safety of CXL to reduce the progression of keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospective, unmasked, randomised, contralateral eye controlled trial at a tertiary eye centre.\n                      <jats:italic>Participants<\/jats:italic>\n                      : Individuals with bilateral progressive keratoconus. One eye from each subject was randomised to CXL and the contralateral, untreated eye acted as the control.\n                      <jats:italic>Primary outcome measure<\/jats:italic>\n                      : change in maximum keratometry.\n                      <jats:italic>Secondary outcome measures<\/jats:italic>\n                      : uncorrected distance visual acuity, spectacle corrected distance visual acuity, spherical equivalent refraction, simulated keratometry, corneal astigmatism, minimum pachymetry and complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight individuals (mean age 21.1\u2009\u00b1\u20096.7\u2009years) were enrolled with one eye treated with CXL. At 5\u2009years, there was a mean decrease in maximum keratometry of treated eyes (\u22121.45\u2009\u00b1\u20092.25 D) compared to an increase among the controls (1.71\u2009\u00b1\u20092.46 D;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). There were significant differences between the treated and control groups in the mean change of Steep SimK (\u22121.07\u2009\u00b1\u20091.22 vs. 0.96\u2009\u00b1\u20091.97 D;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), Flat SimK (\u22120.61\u2009\u00b1\u20091.34 vs. 0.43\u2009\u00b1\u20091.12 D;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), corneal astigmatism (\u22120.45\u2009\u00b1\u20091.31 vs. 0.63\u2009\u00b1\u20091.52 D;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and minimum pachymetry (\u221232.49\u2009\u00b1\u200926.32 vs. \u221213.57\u2009\u00b1\u200924.11\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Complications included sterile infiltrates (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02), microbial keratitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01), persistent corneal haze\/scarring at 5\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04) and loss of \u22652 lines of corrected distance visual acuity (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CXL is an effective and relatively safe intervention to halt or reduce the progression of keratoconus in the majority of eyes for at least 5\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.13959","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T23:58:32Z","timestamp":1623455912000},"page":"542-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Five\u2010year results of a prospective, randomised, contralateral eye trial of corneal crosslinking for keratoconus"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-0652","authenticated-orcid":false,"given":"Jay J.","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-4631","authenticated-orcid":false,"given":"Dipika V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-9420","authenticated-orcid":false,"given":"Akilesh","family":"Gokul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Dean","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suheb","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"},{"name":"Department of Ophthalmology Northern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanu","family":"Subbiah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7048-0706","authenticated-orcid":false,"given":"Charles N. 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