{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:16:19Z","timestamp":1790990179222,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate association between keratoconus and allergic eye diseases, eye rubbing, and atopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Web of Science, Scopus, and Cochrane were searched for relevant published studies from inception to April 2021 without restrictions or filters. We included case\u2013control, cohort, and cross\u2010sectional studies that investigated eye allergy, atopy, or eye rubbing as possible risk factors for KC. Two authors independently screened all titles and abstracts against predefined inclusion and exclusion criteria. This study analysed keratoconus prevalence and risk factors including eye rubbing, family history of keratoconus, atopy, and allergic eye diseases. The National Institute of Health Study Quality Assessment tool was utilised. Pooled data were presented as odds ratio (OR) and 95% confidence intervals (CI). Analysis was conducted using RevMan version 5.3 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 573 articles, we excluded 161 duplicates than 361 articles by title and abstract screening. The remaining 51 articles underwent full\u2010text screening, and 29 articles were excluded. Twenty\u2010one studies were included in the qualitative synthesis and fifteen for quantitative synthesis. There was no significant association found between KC and allergic eye diseases (OR\u00a0=\u00a01.03, 95% CI [0.96, 1.11], <jats:italic>p<\/jats:italic>\u00a0=\u20090.45), eye rubbing (OR\u00a0=\u00a01.59, 95% CI [0.70, 3.63], <jats:italic>p<\/jats:italic>\u00a0=\u20090.27), or atopy (OR\u00a0=\u00a01.08, 95% CI [0.80, 1.44], <jats:italic>p<\/jats:italic>\u00a0=\u20090.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No significant association was observed between KC and allergic eye disease, eye rubbing, or atopy. Further prospective studies are needed to clarify and validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14045","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T14:37:33Z","timestamp":1642689453000},"page":"280-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Retracted:<\/i> The association between keratoconus and allergic eye diseases: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Ishith","family":"Seth","sequence":"first","affiliation":[{"name":"Bendigo Base Hospital  Bendigo Victoria Australia"},{"name":"Department of Ophthalmology Centre for Eye Research Australia  East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bulloch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Centre for Eye Research Australia  East Melbourne Victoria Australia"},{"name":"Faculty of Science, Medicine and Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vine","sequence":"additional","affiliation":[{"name":"Bendigo Base Hospital  Bendigo Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Outmezguine","sequence":"additional","affiliation":[{"name":"Bendigo Base Hospital  Bendigo Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimish","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Surgery Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Every","sequence":"additional","affiliation":[{"name":"Bendigo Base Hospital  Bendigo Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-7005","authenticated-orcid":false,"given":"Mark","family":"Daniell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Centre for Eye Research Australia  East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"370","article-title":"Effects of vernal and allergic conjunctivitis on severity of keratoconus","volume":"6","author":"Cingu AK","year":"2013","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10025-1002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700061"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702692"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8c72"},{"key":"e_1_2_6_9_1","unstructured":"National Eye Institute. 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