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All the involved eyes underwent FL\u2010MILK. The femtosecond laser was used to create an intrastromal pocket with a 2.3\u2009mm incision in the recipient cornea. Then a stromal button with a diameter of 9.0\u2009mm and a depth of 200\u2009\u03bcm was gently inserted into the intrastromal pocket through the 2.3\u2009mm incision and flattened. No sutures were applied. Follow\u2010up was conducted for 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two patients completed follow\u2010up data for 12\u2009months, 16 patients had 24\u2009months follow\u2010up. No epithelial implantation, infection or allogeneic rejection were observed during the follow\u2010up. Based on baseline values, postoperative 12\u2009months values and postoperative 24\u2009months values, clinical significantly improvement was recorded in corrected distance visual acuity (CDVA) (0.40\u2009\u00b1\u20090.18 logMAR vs. 0.30\u2009\u00b1\u20090.12 logMAR and 0.23\u2009\u00b1\u20090.13 logMAR), the anterior central corneal elevation (29.14\u2009\u00b1\u200915.33\u2009\u03bcm vs. 14.45\u2009\u00b1\u200913.75\u03bcm and 11.38\u2009\u00b1\u20098.33\u2009\u03bcm), and corneal higher\u2010order aberrations (3.536\u2009\u00b1\u20091.503 vs. 2.761\u2009\u00b1\u20091.517 and 0.994\u2009\u00b1\u20090.391). Corneal biomechanical properties in all eyes improved significantly. SP\u2010A1 increased from 48.64\u2009\u00b1\u200912.87 preoperatively to 87.26\u2009\u00b1\u200921.01 postoperative 12\u2009months and 88.77\u2009\u00b1\u200918.26 postoperative 24\u2009months; deformation amplitude (DA) decreased from 1.36\u2009\u00b1\u20090.15 preoperatively to 1.21\u2009\u00b1\u20090.12 postoperative 12\u2009months and 1.19\u2009\u00b1\u20090.19 postoperative 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Initial experience suggests that this minimally invasive transplantation may be a feasible option for advanced keratoconus. A larger cohort and longer follow\u2010up are required to validate our results and establish long\u2010term safety and efficacy of the procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14047","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T08:48:52Z","timestamp":1642754932000},"page":"294-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Femtosecond laser\u2010assisted minimally invasive lamellar keratoplasty for the treatment of advanced keratoconus"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-6946","authenticated-orcid":false,"given":"Hua","family":"Gao","sequence":"first","affiliation":[{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"},{"name":"School of Ophthalmology Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingna","family":"Liu","sequence":"additional","affiliation":[{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"},{"name":"School of Ophthalmology Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute Shandong First Medical University &amp; 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