{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:43:34Z","timestamp":1783759414685,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Age\u2010related macular degeneration, a prevalent degenerative retinal disease, is associated with non\u2010visual and psychosocial impairments that may affect sleep. In this systematic review, we evaluated associations between age\u2010related macular degeneration (AMD) and sleep, highlighted knowledge gaps and provided evidence\u2010based recommendations to clinicians to enable holistic management of AMD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Embase and the Cochrane Central registries for papers published before May 2022. Non\u2010English, qualitative studies and grey literature were excluded. Studies evaluating the association between AMD and sleep (including sleep disorders like insomnia and sleep apnea), and vice versa, were included. The quality of shortlisted studies was evaluated using the Newcastle Ottawa Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six (two case\u2013control studies, three longitudinal cohort studies and one cross\u2010sectional study) of 551 studies were included in this review. Four studies found that AMD was associated with increased rates of sleep apnea and poorer reported sleep quality, while five studies showed that patients with sleep apnea or insomnia were at higher risk of developing AMD. Associations between self\u2010reported sleep quantity and AMD were conflicting. No study evaluated the relationship between AMD and sleep using objective sleep assessment tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only a limited number of studies investigated associations between AMD and sleep. These studies suggest a bidirectional relationship between AMD and sleep dysfunction yet disagree on the relationship between sleep quantity and the likelihood of AMD. Additional studies, using objective characterisation of sleep in patients with AMD are required to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14146","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T04:29:32Z","timestamp":1660796972000},"page":"1025-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations between age\u2010related macular degeneration and sleep dysfunction: A systematic review"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-447X","authenticated-orcid":false,"given":"Josh Tjunrong","family":"Sia","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester P. X.","family":"Lee","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chui Ming Gemmy","family":"Cheung","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-2048","authenticated-orcid":false,"given":"Eva K.","family":"Fenwick","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustinus","family":"Laude","sequence":"additional","affiliation":[{"name":"National Healthcare Group Eye Institute Tan Tock Seng Hospital  Singapore Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Chun","family":"Ho","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Discipline of Optometry and Vision Science, Faculty of Health University of Canberra  Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau J.","family":"Fenner","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Milea","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Ophthalmology Department, Rigs Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-5705","authenticated-orcid":false,"given":"Ecosse L.","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-605X","authenticated-orcid":false,"given":"Ryan E. K.","family":"Man","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-2300","authenticated-orcid":false,"given":"Raymond P.","family":"Najjar","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Singapore Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Programme Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Center for Innovation &amp; Precision Eye Health, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.02.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000432401"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S143508"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"103","article-title":"Dry age\u2010related macular degeneration: a currently unmet clinical need","volume":"1","author":"Girmens JF","year":"2012","journal-title":"Intractable Rare Dis Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.4.514"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0145482X0810201003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.185207"},{"issue":"87","key":"e_1_2_7_10_1","first-page":"49","article-title":"Age\u2010related macular degeneration","volume":"27","author":"Mathenge W","year":"2014","journal-title":"Community Eye Health"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730414536852"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare7010001"},{"issue":"5","key":"e_1_2_7_13_1","first-page":"553","article-title":"Sleep deprivation: impact on cognitive performance","volume":"3","author":"Alhola P","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-10-72"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0110-1"},{"issue":"12","key":"e_1_2_7_16_1","first-page":"758","article-title":"The extraordinary importance of sleep: the detrimental effects of inadequate sleep on health and public safety drive an explosion of sleep research","volume":"43","author":"Worley SL","year":"2018","journal-title":"P T"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7172"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0186"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.10.023"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.3.299"},{"issue":"3","key":"e_1_2_7_22_1","first-page":"163","article-title":"Disorders of the sleep\u2010wake cycle in blindness","volume":"29","author":"Adeoti C","year":"2010","journal-title":"West Afr J Med"},{"issue":"11","key":"e_1_2_7_23_1","first-page":"619","article-title":"A study of sleeping disorders in blind patients","volume":"104","author":"Das A","year":"2006","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17357"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20659"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.4\/plfranzen"},{"issue":"9","key":"e_1_2_7_27_1","first-page":"1058","article-title":"Diurnal rhythms in macular degeneration","volume":"12","author":"Hanscom TA","year":"1980","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14071"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-308278"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000247"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(05)80092-X"},{"key":"e_1_2_7_33_1","unstructured":"World Health Organization.ICD\u201010: international statistical classification of diseases and related health problems: tenth revision."},{"key":"e_1_2_7_34_1","unstructured":"GeorgeWells Beverley JShea DO'Connell jePeterson VivianWelch MLosos PeterTugwellThe Newcastle\u2010Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses.2013."},{"key":"e_1_2_7_35_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-154"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14238"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-01973-y"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000706"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2015.1119288"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2009.001230"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1484"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32186-9"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2020.09.18"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107967"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804074-4.00002-9"},{"key":"e_1_2_7_47_1","first-page":"1673","article-title":"Urinary 6\u2010sulfatoxymelatonin level in age\u2010related macular degeneration patients","volume":"15","author":"Rosen R","year":"2009","journal-title":"Mol Vis"},{"issue":"20","key":"e_1_2_7_48_1","first-page":"4196","article-title":"Correlation between serum melatonin and aMT6S level for age\u2010related macular degeneration patients","volume":"20","author":"Lv XD","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14116"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.03.011"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00249-4"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1995.tb00179.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1356.029"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2147-8"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.08.009"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6819736"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02253-5"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000980"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000981"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3142"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa291"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.14146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ceo.14146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.14146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T08:15:31Z","timestamp":1692605731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.14146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/ceo.14146"],"URL":"https:\/\/doi.org\/10.1111\/ceo.14146","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]},"assertion":[{"value":"2022-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}