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Outcome measures were the changes in spherical equivalent (SE) and axial length (AL) from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12\u2009months, the mean SE and AL change from baseline were \u22120.31D (95% confidence interval [CI]\u00a0=\u00a0\u22120.39 to \u22120.22) and 0.16\u2009mm (95%CI\u00a0=\u00a00.13\u20130.20) in the atropine group and \u22120.53D (95%CI\u00a0=\u00a0\u22120.66 to \u22120.40) and 0.25\u2009mm (95%CI\u00a0=\u00a00.20\u20130.30) in the placebo group (group difference <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.01). At 24\u2009months, the mean SE and AL change from baseline was \u22120.64D (95%CI\u00a0=\u00a0\u22120.73 to \u22120.56) and 0.34\u2009mm (95%CI\u00a0=\u00a00.30\u20130.37) in the atropine group, and \u22120.78D (95%CI\u00a0=\u00a0\u22120.91 to \u22120.65) and 0.38\u2009mm (95%CI\u00a0=\u00a00.33\u20130.43) in the placebo group. Group difference at 24\u2009months was not statistically significant (<jats:italic>p<\/jats:italic>\u00a0=\u20090.10). At 24\u2009months, the atropine group had reduced accommodative amplitude and pupillary light response compared to the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Australian children, 0.01% atropine eyedrops were safe, well\u2010tolerated, and had a modest myopia\u2010control effect, although there was an apparent decrease in efficacy between 18 and 24\u2009months, which is likely driven by a higher dropout rate in the placebo group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14148","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T03:49:17Z","timestamp":1661485757000},"page":"1001-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Low\u2010concentration atropine eyedrops for myopia control in a multi\u2010racial cohort of Australian children: A randomised clinical 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