{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:48:48Z","timestamp":1791816528680,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271037"],"award-info":[{"award-number":["81271037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108008"],"award-info":[{"award-number":["81420108008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the long\u2010term efficacy and safety of continued repeated low\u2010level red\u2010light (RLRL) therapy on myopia control over 2\u2009years, and the potential rebound effect after treatment cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Chinese myopic children who originally completed the one\u2010year randomised controlled trial were enrolled. Children continued RLRL\u2010therapy were defined as RLRL\u2010RLRL group, while those who stopped and switched to single\u2010vision spectacle (SVS) in the second year were RLRL\u2010SVS group. Likewise, those who continued to merely wear SVS or received additional RLRL\u2010therapy were SVS\u2010SVS and SVS\u2010RLRL groups, respectively. RLRL\u2010therapy was provided by an at\u2010home desktop light device emitting red\u2010light of 650\u2009nm and was administered for 3\u00a0min at a time, twice a day and 5\u2009days per week. Changes in axial length (AL) and cycloplegic spherical equivalence refraction (SER) were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 199 children who were eligible, 138 (69.3%) children attended the examination and 114 (57.3%) were analysed (SVS\u2010SVS:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a041; SVS\u2010RLRL:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010; RLRL\u2010SVS:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a052; RLRL\u2010RLRL:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011). The baseline characteristics were balanced among four groups. In the second year, the mean changes in AL were 0.28\u2009\u00b1\u20090.14\u2009mm, 0.05\u2009\u00b1\u20090.24\u2009mm, 0.42\u2009\u00b1\u20090.20\u2009mm and 0.12\u2009\u00b1\u20090.16\u2009mm in SVS\u2010SVS, SVS\u2010RLRL, RLRL\u2010SVS and RLRL\u2010RLRL group, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The respective mean SER changes were \u22120.54\u2009\u00b1\u20090.39D, \u22120.09\u2009\u00b1\u20090.55D, \u22120.91\u2009\u00b1\u20090.48D, and \u22120.20\u2009\u00b1\u20090.56D (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Over the 2\u2010year period, axial elongation and SER progression were smallest in RLRL\u2010RLRL group (AL: 0.16\u2009\u00b1\u20090.37\u2009mm; SER: \u22120.31\u2009\u00b1\u20090.79D), followed by SVS\u2010RLRL (AL: 0.44\u2009\u00b1\u20090.37\u2009mm; SER: \u22120.96\u2009\u00b1\u20090.70D), RLRL\u2010SVS (AL: 0.50\u2009\u00b1\u20090.28\u2009mm; SER: \u22121.07\u2009\u00b1\u20090.69D) and SVS\u2010SVS group (AL: 0.64\u2009\u00b1\u20090.29\u2009mm; SER: \u22121.24\u2009\u00b1\u20090.63D). No self\u2010reported adverse events, functional or structural damages were noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Continued RLRL therapy sustained promising efficacy and safety in slowing myopia progression over 2\u2009years. A modest rebound effect was noted after treatment cessation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14149","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T03:43:50Z","timestamp":1661399030000},"page":"1013-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Sustained and rebound effect of repeated low\u2010level red\u2010light therapy on myopia control: A 2\u2010year post\u2010trial follow\u2010up study"],"prefix":"10.1111","volume":"50","author":[{"given":"Ruilin","family":"Xiong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou 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Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Kiburg","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiong","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2010sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou 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Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases  Guangzhou China"},{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"},{"name":"Ophthalmology, Department of Surgery University of Melbourne  Melbourne Victoria 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