{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:40:34Z","timestamp":1793407234595,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1A2C1014798"],"award-info":[{"award-number":["NRF\u20102020R1A2C1014798"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["PJ016130"],"award-info":[{"award-number":["PJ016130"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["PJ016169"],"award-info":[{"award-number":["PJ016169"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dry eye disease is a chronic, progressive ocular disease characterised by ocular discomfort and is one of the most common ophthalmological disorders that affects people's lives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study investigated the clinical efficacy of anthocyanin oligomers (grape skin extract) for the treatment of dry eye. One hundred and eight patients with dry eye were randomly divided into placebo and treatment groups, each with 54 cases. The placebo group received maltodextrin (800\u2009mg\/day) and the treatment group received anthocyanin oligomers (800\u2009mg\/day). Clinical efficacy, clinical indices, and occurrence of adverse reactions were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anthocyanin oligomers were safe and effective in mild\u2010to\u2010moderate dry eye disease, improving the tear break\u2010up time, intraocular pressure, ocular surface disease, and patient symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of oral anthocyanin oligomers in the treatment of dry eye patients can enhance the therapeutic effect and improve the quality of life of patients while ensuring the safety of treatment, making this therapeutic option suitable for wider application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14207","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T04:09:08Z","timestamp":1674792548000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anthocyanin oligomer (grape skin extract) administration improves dry eye disease: A randomised, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"51","author":[{"given":"Meiqi","family":"Fan","sequence":"first","affiliation":[{"name":"Division of Food Bioscience, College of Biomedical and Health Sciences Konkuk University  Chungju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ah.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology SahmYook Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Health Science Dong\u2010A University  Busan Republic of Korea"},{"name":"Center for Silver\u2010targeted Biomaterials, Brain Busan 21 Plus program Dong\u2010A University  Busan Republic of Korea"},{"name":"Department of Health Sciences The Graduate School of Dong\u2010A University  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Tang","sequence":"additional","affiliation":[{"name":"Changchun University of Science and Technology  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Pil","family":"Yang","sequence":"additional","affiliation":[{"name":"Technical R&amp;D Center, Kitto Life Co., LTD  Pyeongtaek Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-6427","authenticated-orcid":false,"given":"Eun\u2010Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Health Science Dong\u2010A University  Busan Republic of Korea"},{"name":"Center for Silver\u2010targeted Biomaterials, Brain Busan 21 Plus program Dong\u2010A University  Busan Republic of Korea"},{"name":"Department of Health Sciences The Graduate School of Dong\u2010A University  Busan Republic of Korea"},{"name":"Center for Food &amp; 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