{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:47:39Z","timestamp":1791229659908,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central retinal vein occlusion and branch retinal vein occlusion are common causes of visual loss due to associated macular oedema. The aim of this review was to assess the effectiveness of interventions improving vision and treating macular oedema in central retinal vein occlusion and branch retinal vein occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical search engines and clinical trial registries were systematically searched. Randomised clinical trials with \u226590 eyes and real\u2010world outcome studies with \u2265100 eyes each with \u22656\u2009months follow\u2010up were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 11 randomised controlled trials evaluating treatments for central retinal vein occlusion which met the inclusion criteria and 10 for branch retinal vein occlusion. There were 10 real world outcome studies of central retinal vein occlusion and 5 real world outcome studies of branch retinal vein occlusion. Meta\u2010analysis was performed on studies that met the defined inclusion criteria. Main outcomes were change in visual acuity at 6\u2010, 12\u2010, 24\u2010 and 36\u2009months by treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravitreal anti\u2010vascular endothelial derived growth factor is recommended as first line treatment over intravitreal corticosteroid due to its effectiveness and lower rate of ocular adverse events. Best outcomes are achieved when intravitreal treatment is started early. Macular laser may have an adjunctive role in branch retina vein occlusion but not central retinal vein occlusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14225","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T04:11:05Z","timestamp":1681531865000},"page":"313-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Management of macular oedema due to retinal vein occlusion: An evidence\u2010based systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-8811","authenticated-orcid":false,"given":"Elisa E.","family":"Cornish","sequence":"first","affiliation":[{"name":"Sydney Medical School, Discipline of Ophthalmology and Eye Health, Save Sight Institute, The University of Sydney  Sydney Australia"},{"name":"Department of Ophthalmology Sydney Eye Hospital  Sydney Australia"},{"name":"Department of 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