{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:37:08Z","timestamp":1782484628824,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3J1651"],"award-info":[{"award-number":["CMRPG3J1651"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the risk of endophthalmitis after cataract surgery in patients with diabetes mellitus (DM) and evaluate the dose\u2013response relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study enrolled patients who underwent bilateral cataract surgeries from 2000 to 2017 in Taiwan National Health Insurance Research Database. The endophthalmitis rates within 3\u2009months after cataract surgery were compared between DM and non\u2010DM cohorts using a generalised estimating equation. The diabetes complications severity index (DSCI) score was adopted to assess the dose\u2013response effect on the endophthalmitis rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 883\u2009398 patients (1\u2009766\u2009796 eyes) were included. Patients with DM had an increased risk of endophthalmitis after cataract surgery than patients without DM (0.261% vs. 0.242%, adjusted odds ratio\u2009=\u20091.09, 95% confidence interval\u2009=\u20091.03\u20131.16). The higher endophthalmitis rate in the DM group than in the non\u2010DM group remains after excluding those with prior vitrectomy or intravitreal injection (IVI), and took IVI between the cataract surgery and endophthalmitis (<jats:italic>p<\/jats:italic>\u2009=\u20090.0156, 0.0048, and 0.0139). There was a significant dose\u2013response relationship on the likelihood of endophthalmitis in DM patients when DCSI score &gt;10. The endophthalmitis rate is highest among DM complications in patients with metabolic disorders (0.342%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DM was a risk factor for endophthalmitis after cataract surgery after adjusting for age, sex, common systemic disorders, and excluding those with prior vitrectomy or IVI and having IVI between cataract surgery and endophthalmitis. A dose\u2013response relationship was noted in DM patients with a DCSI score &gt;10.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14288","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:22:46Z","timestamp":1693290166000},"page":"692-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk and dose\u2013response relationship of diabetes mellitus for endophthalmitis after cataract surgery in a nationwide cohort study in <scp>Taiwan<\/scp>"],"prefix":"10.1111","volume":"51","author":[{"given":"Chiun\u2010Ho","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chang Gung Memorial Hospital at Linkou  Taoyuan Taiwan"},{"name":"Department of Medicine, School of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Institute of Public Health, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of 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