{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:04:06Z","timestamp":1789193046690,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To report the outcomes of low\u2010dose atropine (0.01% and 0.05%) for preventing myopia progression in a real\u2010world Australian cohort during the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of children presenting with myopia, from January 2016 to 2022, were retrospectively reviewed at a comprehensive ophthalmic practice. Children who discontinued treatment, ages &gt;18, and cases with hereditary conditions were excluded. The rate of progression of myopia after treatment with atropine was compared with historical data to evaluate the effectiveness of the regime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and one children (mean baseline spherical equivalent [SphE] [\u22123.70 +\/\u2212 2.09 D] and axial length [AL] [24.59 +\/\u2212 1.00\u2009mm]) were analysed. The mean age of the children was 10.4 +\/\u2212 2.89\u2009years and 61% were females. The average follow\u2010up time was 17.9 +\/\u2212 12.5\u2009months. The mean rate of progression of AL and SphE on 0.01% atropine eyedrops was 0.219 +\/\u2212 0.35\u2009mm and\u2009\u2212\u20090.250 +\/\u2212 0.86\u2009D\/year, respectively. 68.1% of the children treated with 0.01% atropine were mild progressors (&lt;0.5\u2009D change\/year). Non\u2010responders when commenced on a higher dose of atropine (0.05%) experienced a 93% (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) and 30% reduction in SphE and AL growth rate, respectively. Family history, higher myopia or younger age at baseline and shorter duration of treatment were associated with steeper progression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Both doses were well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010dose atropine was shown to be beneficial in a real\u2010world clinical setting, despite interruptions to follow\u2010ups secondary to COVID\u201019 pandemic. A 0.05% dose of atropine may be effective in cases where 0.01% was ineffective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14289","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T23:38:40Z","timestamp":1693438720000},"page":"775-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Real\u2010world outcomes of low\u2010dose atropine therapy on myopia progression in an Australian cohort during the <scp>COVID<\/scp>\u201019 pandemic"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-1526","authenticated-orcid":false,"given":"Eiman","family":"Usmani","sequence":"first","affiliation":[{"name":"Discipline of Ophthalmology and Visual Science University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Ophthalmology Royal Adelaide Hospital and South Australian Institute of Ophthalmology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Callisto","sequence":"additional","affiliation":[{"name":"Discipline of Ophthalmology and Visual Science University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng Onn","family":"Chan","sequence":"additional","affiliation":[{"name":"Discipline of Ophthalmology and Visual Science University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Ophthalmology Royal Adelaide Hospital and South Australian Institute of Ophthalmology  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Taranath","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"237","article-title":"Refractive error blindness","volume":"79","author":"Dandona R","year":"2001","journal-title":"Bull World Health Organ"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442\u20109071.2001.00389.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.06.025"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(12)60272\u20104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.08.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.10.016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071444"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14148"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e213"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.10.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010018\u20100139\u20107"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.3820"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254061"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100131"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2021.101475"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257480"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.5.6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.031"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241759"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2018.10.13"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2011.0027"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/opx.0000000000000178"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/apo.0000000000000414"}],"container-title":["Clinical &amp; 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