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Stem cells have specifically been identified in the cornea, trabecular meshwork, crystalline lens, iris, ciliary body, retina, choroid, sclera, conjunctiva, eyelid, lacrimal gland, and orbital fat. The identification of ocular stem cells broadens the potential therapeutic strategies for untreatable eye diseases. Currently, stem cell transplantation for corneal and conjunctival diseases remains the most common stem cell\u2010based therapy in ocular clinical management. Lens epithelial stem cells have been applied in the treatment of paediatric cataracts. Several early\u2010phase clinical trials for corneal and retinal regeneration using ocular stem cells are also underway. Extensive preclinical studies using ocular stem cells have been conducted, showing encouraging outcomes. Ocular stem cells currently demonstrate great promise in potential treatments of eye diseases. In this review, we focus on the identification, characterisation, and therapeutic application of adult stem cells in the eye.<\/jats:p>","DOI":"10.1111\/ceo.14309","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T08:55:09Z","timestamp":1705049709000},"page":"148-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Adult stem cells in the eye: Identification, characterisation, and therapeutic application in ocular regeneration \u2013 A review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0349-1699","authenticated-orcid":false,"given":"Yuting","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7048-0706","authenticated-orcid":false,"given":"Charles N. 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