{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:52:02Z","timestamp":1747183922415,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate the impact of PreserFlo Microshunt on the ocular surface, focusing on both objective and subjective parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective\u2010observational study on 48 eyes undergoing PreserFlo Microshunt implantation, standalone or combined with phacoemulsification. At baseline, 1\u2010month, 6\u2010months and 12\u2010months post\u2010operative follow\u2010ups, we performed Ocular Surface Disease Index (OSDI) questionnaire, Schirmer's test (ST), Tear\u2010film break\u2010up time (TBUT), fluoresceine staining (FS), tear osmolarity and minimum corneal epithelial thickness (Epi\u2010Thk<jats:sub>MIN.<\/jats:sub>) measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OSDI score improved from 37.43\u2009\u00b1\u200917.49 at baseline, to 24.13\u2009\u00b1\u200912.55 at 1\u2010month (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and to 12.89\u2009\u00b1\u20098.54 and 13.09\u2009\u00b1\u200910.22 at 6\u2010months and 12\u2010months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). TBUT and ST, in a similar way, non\u2010significantly increased at 1\u2010month, but then improved at 6\u2010months and 12\u2010months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for both). Tear osmolarity significantly decreased from 308.2\u2009\u00b1\u20097.3\u2009mOsm\/L at baseline, to 303.3\u2009\u00b1\u20098.2\u2009mOsm\/L, 295.6.2\u2009\u00b1\u20097.0\u2009mOsm\/L and 297.6\u2009\u00b1\u20096.8\u2009mOsm\/L at 1\u2010month, 6\u2010months and 12\u2010months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for all). Epi\u2010Thk<jats:sub>MIN<\/jats:sub> was stable when comparing baseline (44.9\u2009\u00b1\u20095.7\u2009\u03bcm) and 1\u2010month (<jats:italic>p<\/jats:italic>\u2009=\u20090.28), and successively increased in 6\u2010months (47.8\u2009\u00b1\u20095.5\u2009\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and 12\u2010months (48.0\u2009\u00b1\u20093.6\u2009\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). In subgroup analysis, OSDI score and tear osmolarity were significantly higher at 1\u2010month in combined group compared to standalone group (<jats:italic>p<\/jats:italic>\u2009=\u20090.03 and <jats:italic>p<\/jats:italic>\u2009=\u20090.02, respectively), but reaching comparable values in successive follow\u2010ups. Further, Oxford scale grades for FS were significantly improved when comparing baseline\u20136\u2010months and baseline\u201312\u2010months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PreserFlo implantation improved ocular surface subjective symptoms, increased TBUT and ST, and reduced FS, highlighting the potential benefits of this surgical intervention. Moreover, we reported significant improvements of tear osmolarity and corneal epithelium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14320","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:37:04Z","timestamp":1700602624000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of ocular surface following <scp>PreserFlo Microshunt<\/scp> implantation: Functional outcomes and quality of life"],"prefix":"10.1111","volume":"52","author":[{"given":"Gloria","family":"Gambini","sequence":"first","affiliation":[{"name":"Ophthalmology Department Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"},{"name":"Ophthalmology Department Catholic University \u201cSacro Cuore\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1638","authenticated-orcid":false,"given":"Matteo Mario","family":"Carl\u00e0","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"},{"name":"Ophthalmology Department Catholic University \u201cSacro Cuore\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Giannuzzi","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"},{"name":"Ophthalmology Department Catholic University \u201cSacro Cuore\u201d  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-6567","authenticated-orcid":false,"given":"Alfonso","family":"Savastano","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Fondazione Policlinico Universitario A. 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