{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:39:06Z","timestamp":1789987146893,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["#2008382"],"award-info":[{"award-number":["#2008382"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1027624"],"award-info":[{"award-number":["APP1027624"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1194667"],"award-info":[{"award-number":["GNT1194667"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BM\u2010AXIS program"],"award-info":[{"award-number":["BM\u2010AXIS program"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009399","name":"Macular Disease Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To examine the association between large choroidal signal hypertransmission \u2265250\u2009\u03bcm (LHyperT) on optical coherence tomography (OCT) with the risk of developing geographic atrophy (GA) and compare this risk with those associated with <jats:italic>nascent geographic atrophy<\/jats:italic> (nGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and eighty eyes from 140 participants with bilateral large drusen and without late age\u2010related macular degeneration (AMD) or nGA at baseline underwent OCT imaging and colour fundus photography (CFP) at 6\u2010monthly intervals up to 5\u2009years. OCT scans were graded for the presence of LHyperT and nGA, and CFPs were graded for the presence of GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The five\u2010year incidence of LHyperT and nGA were 37% and 27% respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), and the two\u2010year probability of their progression to GA were 17% and 40%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). LHyperT and nGA explained 81% and 91% of the variance in the time to develop GA, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.032), and they were both associated with a significantly higher rate of GA development compared to eyes without these lesions (adjusted hazard ratio\u2009=\u2009110.8 and 183.2, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LHyperT and nGA were both high\u2010risk features for GA development, but the latter showed a higher rate of GA progression and explained a significantly greater proportion of the variance in the time to develop GA. As such, nGA may be a more robust surrogate endpoint than LHyperT for the conventional clinical endpoint of CFP\u2010defined GA for intervention trials in the early stages of AMD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14356","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T01:53:58Z","timestamp":1706579638000},"page":"431-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Choroidal signal hypertransmission on optical coherence tomography imaging: Association with development of geographic atrophy in age\u2010related macular degeneration"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8623-6684","authenticated-orcid":false,"given":"Zhichao","family":"Wu","sequence":"first","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"},{"name":"Ophthalmology, Department of Surgery The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Terheyden","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A. B.","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-4356","authenticated-orcid":false,"given":"Robyn H.","family":"Guymer","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"},{"name":"Ophthalmology, Department of Surgery The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1417"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4997"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.06.034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15614"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16211"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-21696"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.12.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.09.028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.035"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2021.01.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.6067"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.09.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510887"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.11.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.12.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.07.019"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175110"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.09.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.07.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.06.026"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-315935"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.09.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.07.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.02.015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.01.011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.02.004"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.03.012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1348\/000711006X126600"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.07.003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003158"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.03.008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003929"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.14356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T04:19:47Z","timestamp":1717733987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.14356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ceo.14356"],"URL":"https:\/\/doi.org\/10.1111\/ceo.14356","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}