{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:09:11Z","timestamp":1787076551906,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001108","name":"Ophthalmic Research Institute of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001063","name":"Raine Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020971","name":"Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023759","name":"Telethon Kids Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A rebound in myopia progression following cessation of atropine eyedrops has been reported, yet there is limited data on the effects of stopping 0.01% atropine compared to placebo control. This study tested the hypothesis that there is minimal rebound myopia progression after cessation of 0.01% atropine eyedrops, compared to a placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children with myopia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009153) were randomised to receive 0.01% atropine eyedrops or a placebo (2:1 ratio) daily at bedtime during the 2\u2010year treatment phase of the study. In the third year (wash\u2010out phase), all participants ceased eyedrop instillation. Participants underwent an eye examination every 6\u2009months, including measurements of spherical equivalent (SphE) after cycloplegia and axial length (AL). Changes in the SphE and AL during the wash\u2010out phase and throughout the 3\u2009years of the study (treatment\u2009+\u2009wash\u2010out phase) were compared between the treatment and control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the 1\u2010year wash\u2010out phase, SphE and AL progressed by \u22120.41D (95% CI\u2009=\u2009\u22120.33 to \u22120.22) and +0.20\u2009mm (95% CI\u2009=\u2009\u22120.46 to \u22120.36) in the treatment group compared to \u22120.28D (95% CI\u2009=\u20090.11 to 0.16) and +0.13\u2009mm (95% CI\u2009=\u20090.18 to 0.21) in the control group. Progression in the treatment group was significantly faster than in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016 for SphE and &lt;0.001 for AL). Over the 3\u2010year study period, the cumulative myopia progression was similar between the atropine and the control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings showed evidence of rapid myopia progression following cessation of 0.01% atropine. Further investigations are warranted to ascertain the long\u2010term effects of atropine eyedrops.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14368","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T02:19:25Z","timestamp":1708741165000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Myopia progression following 0.01% atropine cessation in Australian children: Findings from the Western Australia \u2013 Atropine for the Treatment of Myopia (\n                    <scp>WA\u2010ATOM<\/scp>\n                    ) study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6635-1098","authenticated-orcid":false,"given":"Samantha Sze\u2010Yee","family":"Lee","sequence":"first","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute) University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-6582","authenticated-orcid":false,"given":"Vinay Kumar","family":"Nilagiri","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute) University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-0733","authenticated-orcid":false,"given":"Gareth","family":"Lingham","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology and Visual Science (incorporating the Lions Eye Institute) University of Western Australia  Perth Western Australia Australia"},{"name":"Centre for Eye Research Ireland, Environmental, Sustainability and Health Institute Technological University Dublin  Dublin 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