{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:53:43Z","timestamp":1775188423725,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010000531\u201000"],"award-info":[{"award-number":["MOH\u2010000531\u201000"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010001103\u201000"],"award-info":[{"award-number":["MOH\u2010001103\u201000"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007419","name":"Lee Foundation","doi-asserted-by":"publisher","award":["TLF1021\u20103"],"award-info":[{"award-number":["TLF1021\u20103"]}],"id":[{"id":"10.13039\/100007419","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007419","name":"Lee Foundation","doi-asserted-by":"publisher","award":["TLF 0322\u20108"],"award-info":[{"award-number":["TLF 0322\u20108"]}],"id":[{"id":"10.13039\/100007419","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A high\u2010frequency point\u2010of\u2010care (POC) ultrasound instrument was used to evaluate the microstructural and biomechanical properties of the anterior sclera in vivo using parameters computed from quantitative ultrasound (QUS) methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, both eyes of 85 enrolled patients were scanned with the POC instrument and ultrasound data were processed to obtain QUS parameters. Pearson correlation and multi\u2010linear regression were used to identify relationships between QUS parameters and refractive error (RE) or axial length. After categorising eyes based on RE, binary support vector machine (SVM) classifiers were trained using the QUS or ophthalmic parameters (anterior chamber depth, central corneal thickness, corneal power, and intraocular pressure) to classify each eye. Classifier performance was evaluated by computing the area under the receiver\u2010operating characteristic curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individual QUS parameters correlated with RE and axial length (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Multi\u2010linear regression revealed significant correlation between the set of QUS parameters and both RE (<jats:italic>R<\/jats:italic>\u2009=\u20090.49, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and axial length (<jats:italic>R<\/jats:italic>\u2009=\u20090.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Classifiers trained with QUS parameters achieved higher AUC (\ud835\udc5d =\u20090.06) for identifying myopic eyes (AUC\u2009=\u20090.71) compared to classifiers trained with ophthalmic parameters (AUC\u2009=\u20090.63). QUS\u2010based classifiers attained the highest AUC when identifying highly myopic eyes (AUC\u2009=\u20090.77).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>QUS parameters correlate with progressing myopia and may be indicative of myopia\u2010induced microstructural and biomechanical changes in the anterior sclera. These methods may provide critical clinical information complementary to standard ophthalmic measurements for predicting myopia progression and risk assessment for posterior staphyloma formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14415","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:54:42Z","timestamp":1720140882000},"page":"840-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In\u2010vivo high\u2010frequency quantitative ultrasound\u2010derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-095X","authenticated-orcid":false,"given":"Cameron","family":"Hoerig","sequence":"first","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan V.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Centre  Duke\u2010NUS Singapore"},{"name":"Ophthalmology, Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Department of Ophthalmology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Mamou","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"The Myopias: Basic Science and Clinical Management","author":"Curtin 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