{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:05:11Z","timestamp":1792202711741,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301172"],"award-info":[{"award-number":["82301172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011167"],"award-info":[{"award-number":["2024A1515011167"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate prognostic factors for primary ocular adnexal lymphoma (POAL) are scarce. Survival models and prognostic factors derived without considering competing risk factors suffer from major statistical errors. This study aimed to accurately assess prognostic factors in POAL patients using competing risk models, and compare this to the traditional COX proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study utilised data from the Surveillance, Epidemiology, and End Results (SEER) program 2010\u20132015 and included patients with B\u2010cell POAL. The cumulative incidence function and Gray's test for cause\u2010specific survival were calculated as univariate analysis. The competing risk models were a Fine\u2010Gray subdistribution hazard model and a cause\u2010specific model, and a traditional COX model was employed as a multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study enrolled 846 eligible patients with POAL: 60 patients (7.09%) died from POAL and 123 patients (14.54%) died from other causes. Multivariate competing risk models indicated that age, laterality, histology subtype, the 7th edition of American Joint Committee on Cancer stage T, and radiotherapy were independent predictors for cause\u2010specific survival of patients with POAL. There was high consistency between the two competing risk models. The COX model made several misestimations on the statistical significance and hazard ratios of prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study established competing risk models as a method to assess POAL prognostic factors, which was more accurate than traditional methods that do not consider competing risk elements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14427","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T01:18:42Z","timestamp":1722561522000},"page":"991-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of prognostic factors in patients with primary ocular adnexal lymphoma when considering competing risk elements"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8390-5820","authenticated-orcid":false,"given":"Jing","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Ophthalmic Center, The Second Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Fen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Department of Ophthalmology The First People's Hospital of Chenzhou  Chenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9497-4161","authenticated-orcid":false,"given":"Zhi\u2010ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Ophthalmic Center, The Second Affiliated Hospital Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Clinical Research The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Surveillance Epidemiology and End Results Program.Surveillance Epidemiology and End Results Program Website National Cancer Institute United States government.2023https:\/\/seer.cancer.gov\/statfacts\/"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/eop.11.16"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2019.1704032"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-315875"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14122"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"50","article-title":"How to use the surveillance, epidemiology, and end results (SEER) data: research design and methodology","volume":"10","author":"Che WQ","year":"2023","journal-title":"Mil Med Res"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12548"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.037"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp107"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304847"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"218","article-title":"Clinical staging classification of non\u2010Hodgkin's lymphomas (author's transl)","volume":"153","author":"Musshoff K","year":"1977","journal-title":"Strahlentherapie"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000224"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2022.10.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-1477-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm457"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18500"}],"container-title":["Clinical &amp; 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