{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:13:08Z","timestamp":1781586788435,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To describe the incidence and pattern of reactivation of neovascular age\u2010related macular degeneration (nAMD) following successful treatment with treat\u2010and\u2010extend intravitreal anti\u2010vascular endothelial growth factor therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with treated nAMD who did not require further treatment over a 6\u2010month period and who attended their 3\u2010monthly optical coherence tomography monitoring clinic in Moorfields Eye Hospital from 1 November 2019 to 31 January 2020 were included. Patients with diagnoses of macular neovascularization other than AMD, and patients with incomplete data were excluded. Baseline demographics recorded were age, sex, race, laterality, cause of macular neovascularization, drug, number of injections, and duration of treatment. Date, setting, symptoms, and time to retreatment were collected among patients with disease reactivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The medical records of 286 patients were included. Most patients were female (64.3%), white (68.18%), and were receiving aflibercept monotherapy (55.2%). Mean number of injections at baseline was 17.79\u2009\u00b1\u200911.74 (range 3\u201362) with a mean treatment duration of 39.47\u2009\u00b1\u200930.68\u2009months (range 2\u2013139). Reactivation of AMD was identified in 32.2% of cases with 87% of recurrences identified via scheduled visit. The most common symptom was blurring of vision in 44.6%, while 39.1% were asymptomatic. Mean time from baseline to retreatment was 29.37\u2009\u00b1\u200922.40\u2009months (range 5\u2013104), with 20.7%, 73.9% and 88.04% of these patients requiring retreatment within 1, 3, and 5\u2009years, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite prior treatment with no reactivation in 6\u2009months, 32.2% reactivate, 73.9% of which within 3\u2009years. A significant proportion, 39.1%, reactivated without symptoms necessitating regular monitoring in the first 5\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14444","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T07:24:42Z","timestamp":1727853882000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reactivation of stable neovascular age\u2010related macular degeneration following treat\u2010and\u2010extend regimen discontinuation"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-7968","authenticated-orcid":false,"given":"Jose Carlo M.","family":"Artiaga","sequence":"first","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"Department of Ophthalmology and Visual Sciences Philippine General Hospital, University of the Philippines Manila  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-5984","authenticated-orcid":false,"given":"Shiao Wei","family":"Wong","sequence":"additional","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"Manchester Royal Eye Hospital Manchester University Hospitals NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthy","family":"Menon","sequence":"additional","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Kumar","sequence":"additional","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-0248","authenticated-orcid":false,"given":"Pankaja","family":"Dhoble","sequence":"additional","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Thottarath","sequence":"additional","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6685-4402","authenticated-orcid":false,"given":"Luke","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Medical Retina Service Moorfields Eye Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.15.1900"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31550-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-019-4666-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.03.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.07.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.07.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.5540"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01510-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjhci-2020-100310"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S349939"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.03.033"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1357633X20960636"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.02.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00757-2"},{"key":"e_1_2_7_18_1","article-title":"Impact of COVID \u201019 restrictions on the treatment of neovascular age\u2010related macular degeneration","volume":"102","author":"Bagi Nordsten C","year":"2023","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2022.08.002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15206"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-022-02453-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.05.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1204026"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01562-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19062-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","DOI":"10.1097\/IAE.0000000000001923","article-title":"Exit strategy in a treat\u2010and\u2010extend regimen for exudative age\u2010related macular degeneration","volume":"39","author":"Arendt P","year":"2019","journal-title":"Retina"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S334641"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.01.011"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311494"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2023.2178661"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14520"},{"key":"e_1_2_7_32_1","article-title":"Treatment patterns and visual acuity change of AMD patients, before, during and after the COVID\u201019 pandemic lockdowns: a large cohort","volume":"102","author":"Barequet D","year":"2023","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59030490"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316882"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0964-3"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.104"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-022-00632-6"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.14444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T23:35:07Z","timestamp":1743896107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.14444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ceo.14444"],"URL":"https:\/\/doi.org\/10.1111\/ceo.14444","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]},"assertion":[{"value":"2024-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}