{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:00:26Z","timestamp":1768464026993,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Uveal melanoma (UM) can be classified by tumour size category and by The Cancer Genome Atlas (TCGA) groups (cytogenetic\u2010based, 4\u2010category prognostic classification into Groups A\u2010D). This study was conducted to assess impact on metastasis\u2010free survival (MFS) in UM by tumour size category based on correlation with TCGA classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 1001 cases categorised as small (0.0\u20133.0\u2009mm), medium (3.1\u20138.0\u2009mm) and large (\u22658.1\u2009mm), grouped by TCGA classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1001 cases, TCGA Groups (A\/B\/C\/D) included small (<jats:italic>n<\/jats:italic>\u2009=\u2009270, 75%\/11%\/13%\/1%), medium (<jats:italic>n<\/jats:italic>\u2009=\u2009503, 46%\/14%\/27%\/13%) and large (<jats:italic>n<\/jats:italic>\u2009=\u2009228, 23%\/19%\/38%\/20%) UM. The 5\u2010and 10\u2010year Kaplan\u2013Meier MFS for small UM revealed Group A (98%, 98%), Group B (100%, 100%), Group C (86%, NA) and Group D (100%, NA). For medium UM, the values dropped with Group A (95%, 93%), Group B (90%, 90%), Group C (68%, 38%), and Group D (44%, NA). For large UM, the values dropped further with Group A (94%, 86%), Group B (85%, NA), Group C (40%, 28%), and Group D (23%, NA). Additionally, a comparison (small vs. medium vs. large tumour size category) revealed TCGA low\u2010risk grouping (Groups A or B) in 86% vs. 60% vs. 58% cases with UM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>By tumour size category, favourable cytogenetics (Groups A or B) is found in 86% of small tumours, 60% of medium tumours, and 58% of large tumours. The MFS at 10\u2009years for favourable cytogenetics was 98% for small tumours, 92% for medium tumours, and 54% for large tumours. Tumour size category can serve as a surrogate for TCGA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14446","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T10:35:10Z","timestamp":1728038110000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metastasis\u2010free survival of uveal melanoma by tumour size category based on The Cancer Genome Atlas (<scp>TCGA<\/scp>) classification in 1001 cases"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-0482","authenticated-orcid":false,"given":"Rolika","family":"Bansal","sequence":"first","affiliation":[{"name":"Ocular Oncology Service Wills Eye Hospital, Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-0170","authenticated-orcid":false,"given":"Hidayet","family":"Sener","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service Wills Eye Hospital, Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arupa","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry A.","family":"Shields","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service Wills Eye Hospital, Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-3632","authenticated-orcid":false,"given":"Carol L.","family":"Shields","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service Wills Eye Hospital, Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.32.10.729"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.22608\/APO.201734"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000051"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1589_19"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00182-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00607-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00077-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.208"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_313_21"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjopt.sjopt_69_21"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13580"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.3.31"},{"key":"e_1_2_8_14_1","first-page":"131","article-title":"Malignant melanotic tumors of the eye: a study of histopathologic types in 111 cases. 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