{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:21:39Z","timestamp":1743913299373,"version":"3.40.3"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether non\u2010syndromic connective tissue hyperlaxity is associated with myopia is unknown. The aim of this study was to examine the association between systemic signs of tissue hyperlaxity and myopia among adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included were adolescents assessed before mandatory military service at the age of 16\u201318\u2009years between 2011 and 2022. Diagnoses of hernias, pes planus, genu varus, genu valgum, and scoliosis, as well as joint injuries were used as surrogate markers for tissue hyperlaxity. The prevalence of these events among adolescents with myopia was evaluated and compared to the non\u2010myopic population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Included were 920\u2009806 adolescents. The mean age was 17.4\u2009\u00b1\u20091.4\u2009years and 58.6% were men. Myopia was diagnosed in 290\u2009759 adolescents (31.6%) and high myopia in 24\u2009069 adolescents (2.6%). The prevalence of hernias was higher among adolescents with myopia, (2.76%, 95% confidence interval (95% CI): 2.69%\u20132.82% vs. 2.60%, 95% CI: 2.57%\u20132.65%), as were pes planus (14.92%, 95% CI: 14.79\u201315.05 vs. 13.51%, 95% CI: 13.42\u201313.59) and scoliosis (9.14%, 95% CI: 9.03\u20139.24 vs. 7.69%, 95%CI: 7.62\u20137.76). The prevalence of joint injuries was clinically similar between groups (less than 0.1% difference for ankle, shoulder, and knee injuries), as were genu varum and genu valgum (0.66%, 95%CI: 0.64%\u20130.69% vs. 0.68%, 95% CI: 0.66\u20130.70, respectively). Adjusted for possible confounders results remained consistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among a large sample of Israeli adolescents, those with myopia had a higher prevalence of hernias, pes planus, and scoliosis. These results could suggest a propensity for systemic conditions related to tissue laxity among myopic adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14450","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T16:20:53Z","timestamp":1728404453000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myopia and systemic manifestation of tissue hyperlaxity: A population\u2010based cross\u2010sectional study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-0432","authenticated-orcid":false,"given":"Idan","family":"Hecht","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shamir Medical Center (formerly Assaf\u2010Harofeh)  Be'er Ya'akov Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 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