{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:03:59Z","timestamp":1790139839649,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016888","name":"Bayer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011369","name":"Royal Australian and New Zealand College of Ophthalmologists","doi-asserted-by":"publisher","award":["2007\u20102009"],"award-info":[{"award-number":["2007\u20102009"]}],"id":[{"id":"10.13039\/100011369","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["NHMRC 2010\u20101012"],"award-info":[{"award-number":["NHMRC 2010\u20101012"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to describe a 2\u2010year outcome of eyes managed by practitioners benchmarked using a funnel plot by their frequency of treatment using vascular endothelial growth factor (VEGF) inhibitors for naive retinal vein occlusion (RVO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre, international, observational study of 29 doctors in 12 countries managing 1110 eyes with RVO commencing VEGF inhibitors between 1 January 2012\u20132022 tracked in the Fight Retinal Blindness! registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 3 outlying \u2018intensive\u2019 practitioners (managing 350\/1110 eyes [32%]), 22 \u2018typical\u2019 practitioners (604\/1110, [54%]) and 4 outlying \u2018relaxed\u2019 practitioners (156\/1110, [14%]) with respective 24\u2010month outcomes in Branch and Central RVO including the primary outcome, mean adjusted change in visual acuity (VA) in BRVO: +16.2, +13.6, +9.3 letters (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and CRVO: +14.2, +12.7, +4.8 letters (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01); adjusted change in macular thickness in BRVO \u2212179, \u2212150, \u2212159\u2009\u03bcm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and CRVO \u2212324, \u2212283, \u2212232\u2009\u03bcm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01); time\u2010in\u2010range with VA &gt;\u200968 letters in BRVO 90, 78, 68\u2009weeks (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and CRVO 69, 60, 54\u2009weeks (<jats:italic>p<\/jats:italic>\u2009=\u20090.04); median injections 18, 13 and 10; median final injection intervals, BRVO 6, 9, 10\u2009weeks and CRVO 6, 9 and 12\u2009weeks; with no significant difference in adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 24\u2009months, the intensive practitioners were treating RVO using VEGF inhibitors with twice the frequency of the relaxed practitioners; however, their patients had gained twice (BRVO) to three times (CRVO) more letters of VA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14490","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T08:49:23Z","timestamp":1735375763000},"page":"409-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outliers of Treatment Frequency in Retinal Vein Occlusion: 24\u2010Month Comparative Analysis of Fight Retinal\u00a0Blindness! Practitioners"],"prefix":"10.1111","volume":"53","author":[{"given":"Theodorus","family":"Ponsioen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Isala  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"The Save Sight Institute, Sydney Medical School, the University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-1987","authenticated-orcid":false,"given":"Alessandro","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"The Save Sight Institute, Sydney Medical School, the University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Biomedical and Clinical Science Luigi Sacco Hospital, University of Milan  Milan 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