{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:56:11Z","timestamp":1792112171982,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1082358"],"award-info":[{"award-number":["1082358"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To assess the safety and stability profile of the suprachoroidal retinal prosthesis (ScRP) in participants with retinitis pigmentosa (RP) for 2\u2009years from implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four participants, with advanced RP and bare\u2010light perception vision were enrolled in a prospective, single arm unmasked interventional clinical trial and unilaterally implanted with a 44\u2010channel ScRP (NCT03406416). Electrical stimulation commenced in the psychophysics laboratory prior to use in local environments. Outcome measures included serious adverse events, adverse events, implant stability and implant functionality to assess the safety and stability profile over 2.0\u20132.7\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Surgical procedures took 204\u2013260\u2009min and were uncomplicated. Postoperative recovery was uneventful. Imaging confirmed the device position under the macula and the absence of retinal trauma. There were no serious adverse events and the adverse events that occurred were mild. All electrodes were functional at surgery completion, and only 3% electrodes lost functionality by study end. There was minor array movement (translational and rotational) within the first 10\u201315\u2009weeks only. The electrode to retina distance increased as expected with fibrous capsule development, but plateaued in three of four participants within 12\u2009months. Retinal and choroidal thicknesses were consistent with the underlying retinal dystrophic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ScRP can be safely implanted in the suprachoroidal space and has minimal long\u2010term impacts on the eye, with no SAEs and only slight array movement seen over 2.0\u20132.7\u2009years. Hence, the findings indicate approach feasibility and further multicentre studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14502","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T03:49:14Z","timestamp":1738295354000},"page":"529-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Second\u2010Generation (44\u2010Channel) Suprachoroidal Retinal Prosthesis: Surgical Stability and Safety During a 2\u2010Year Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-1253","authenticated-orcid":false,"given":"Penelope J.","family":"Allen","sequence":"first","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"},{"name":"Department of Surgery (Ophthalmology) University of Melbourne  Melbourne Victoria Australia"},{"name":"Vitreoretinal Unit Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-3264","authenticated-orcid":false,"given":"Maria","family":"Kolic","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1754-9310","authenticated-orcid":false,"given":"Elizabeth K.","family":"Baglin","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8312-2924","authenticated-orcid":false,"given":"Samuel A.","family":"Titchener","sequence":"additional","affiliation":[{"name":"Bionics Institute  Melbourne Victoria Australia"},{"name":"Medical Bionics Department University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-1832","authenticated-orcid":false,"given":"Jessica","family":"Kvansakul","sequence":"additional","affiliation":[{"name":"Bionics Institute  Melbourne Victoria Australia"},{"name":"Medical Bionics Department University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4380-6640","authenticated-orcid":false,"given":"David A. X.","family":"Nayagam","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"},{"name":"Department of Clinical Pathology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1601-2861","authenticated-orcid":false,"given":"Jonathan","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"},{"name":"Vitreoretinal Unit Royal Victorian Eye and Ear Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2302-8468","authenticated-orcid":false,"given":"Robert J.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Surgery (Otolaryngology) University of Melbourne  Melbourne Victoria 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