{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:10:39Z","timestamp":1790799039009,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T00:00:00Z","timestamp":1739059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To examine if there was a monthly variation in HLA\u2010B27\u2010associated uveitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of all individuals presenting to a single centre with HLA\u2010B27\u2010associated uveitis from 2009 to\u00a02020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      577 participants with HLA\u2010B27\u2010associated uveitis were included. The median age at presentation was 40.4\u2009years (IQR 31.1\u201351.4) and 356 (61.7%) were male. 141 (24.4%) participants were diagnosed with ankylosing spondylitis. The incidence of HLA\u2010B27 uveitis was greatest in August (winter) and lowest in March (autumn). On univariate analysis, there was an inverse relationship between HLA\u2010B27\u2010associated uveitis incidence and mean air temperature (\u03b2\u22122.704,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and sunlight hours (\u03b2\u22120.221,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and a positive relationship between uveitis incidence and rainfall (\u03b2 0.324,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and humidity (\u03b2 1.741,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). On multivariate analysis, there was an inverse relationship with temperature (\u03b2\u22124.846,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and a positive association with humidity (\u03b2 2.033,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). On multivariate analysis, the impact of rainfall shifted to negative (\u03b2\u22120.446,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and sunlight hours lost significance. The monthly effect was more pronounced for non\u2010Caucasian ethnicities and for those without ankylosing spondylitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In New Zealand, HLA\u2010B27\u2010associated uveitis episodes are influenced by monthly changes with higher incidence in winter months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14503","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:48:35Z","timestamp":1739234915000},"page":"516-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Seasonal Variation in\n                    <scp>HLA<\/scp>\n                    \u2010\n                    <scp>B27<\/scp>\n                    Associated Uveitis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-4707","authenticated-orcid":false,"given":"Priya D.","family":"Samalia","sequence":"first","affiliation":[{"name":"Health New Zealand  Auckland New Zealand"},{"name":"Health New Zealand Southern  Dunedin New Zealand"},{"name":"University of Otago  Dunedin New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Brodie","sequence":"additional","affiliation":[{"name":"Health New Zealand  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Sims","sequence":"additional","affiliation":[{"name":"Health New Zealand  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael L.","family":"Niederer","sequence":"additional","affiliation":[{"name":"Health New Zealand  Auckland New Zealand"},{"name":"University of Auckland  Auckland New 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