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Pathogenic variants in genes encoding many of these proteins can give rise to significant vision impairment, accounting for a substantial portion of inherited retinal disease. Such genes include <jats:italic>RHO<\/jats:italic>, <jats:italic>OPN1LW<\/jats:italic>, <jats:italic>OPN1MW<\/jats:italic>, <jats:italic>GNAT1<\/jats:italic>, <jats:italic>GNAT2<\/jats:italic>, <jats:italic>GNB3<\/jats:italic>, <jats:italic>PDE6A<\/jats:italic>, <jats:italic>PDE6B<\/jats:italic>, <jats:italic>PDE6G<\/jats:italic>, <jats:italic>PDE6C<\/jats:italic>, <jats:italic>PDE6H<\/jats:italic>, <jats:italic>CNGA1<\/jats:italic>, <jats:italic>CNGB1<\/jats:italic>, <jats:italic>CNGA3<\/jats:italic>, <jats:italic>CNGB3<\/jats:italic>, <jats:italic>GRK1<\/jats:italic>, <jats:italic>SAG<\/jats:italic>, <jats:italic>ARR3<\/jats:italic>, <jats:italic>RGS9<\/jats:italic>, <jats:italic>RGS9BP<\/jats:italic>, <jats:italic>GUCY2D<\/jats:italic>, <jats:italic>GUCA1A<\/jats:italic> and <jats:italic>SLC24A1<\/jats:italic>. Many of these conditions have distinct mechanisms and clinical features. They follow several modes of inheritance (including in one case digenic, or tri\u2010allelic, inheritance). Some conditions also entail myopia. Rod and cone phototransduction will be outlined, followed by the discussion of diseases associated with these genes. Some phenotypic features will be highlighted as well as their prevalence in a large genotyped inherited retinal disease cohort.<\/jats:p>","DOI":"10.1111\/ceo.14511","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T18:34:19Z","timestamp":1741199659000},"page":"260-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review"],"prefix":"10.1111","volume":"53","author":[{"given":"Wendy M.","family":"Wong","sequence":"first","affiliation":[{"name":"Institute of Ophthalmology, University College London  London UK"},{"name":"NIHR Biomedical Research Centre at Moorfields Eye Hospital and the UCL Institute of Ophthalmology  London UK"},{"name":"Centre for Innovation &amp; Precision Eye Health, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Ophthalmology, National University Hospital National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-0832","authenticated-orcid":false,"given":"Omar A.","family":"Mahroo","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, University College London  London UK"},{"name":"NIHR Biomedical Research Centre at Moorfields Eye Hospital and the UCL Institute of Ophthalmology  London UK"},{"name":"Section of Ophthalmology, King's College London St Thomas' Hospital Campus  London UK"},{"name":"Physiology, Development and Neuroscience University of Cambridge  Cambridge UK"},{"name":"Department of Translational Ophthalmology Wills Eye Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282058"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2022.08.010"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101116"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.07.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-021-02551-0"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.100823"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711970"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-100820-083937"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01604-z"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV120.014405"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.101013"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.04.008"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019111"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.12.003"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02491-2"},{"issue":"2","key":"e_1_2_13_17_1","first-page":"635","article-title":"A Proximal Retinal Component in the Primate Photopic ERG a\u2010Wave","volume":"35","author":"Bush R. 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