{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:18:26Z","timestamp":1768555106765,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["G2021016S"],"award-info":[{"award-number":["G2021016S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare the performance of high\u2010resolution microperimetry testing against standard automated perimetry (SAP) for detecting glaucomatous damage seen on optical coherence tomography (OCT) scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>250 eyes from 200 individuals underwent high\u2010resolution microperimetry testing of a hemifield using a stimulus pattern optimised to sample typical arcuate patterns of visual field loss in glaucoma. SAP was performed using a 24\u20132 stimulus pattern. The presence of glaucomatous damage in each hemifield was subsequently independently assessed by two graders based on a circumpapillary OCT circle scan, 6\u00d76\u2009mm optic disc\u2010centred OCT volume scan, and 15\u00d715\u2009mm widefield OCT volume scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hemifield\u2010based mean total deviation (MTD) and pointwise sensitivity standard deviation (PSD) for high\u2010resolution microperimetry and SAP were both independently associated with the presence of glaucomatous damage in multivariable logistic regression analyses (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.046). Prediction models developed using these two parameters showed significantly higher performance with high\u2010resolution microperimetry compared to SAP (partial area under the receiver operating characteristic curve [pAUC]\u2009=\u20090.86 and 0.75 respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.007). The performance of microperimetry decreased with decreasing resolution when the MTD and PSD values were derived from every second, third, and sixth test locations (pAUC\u2009=\u20090.85 [<jats:italic>p<\/jats:italic>\u2009=\u20090.16], 0.85 [<jats:italic>p<\/jats:italic>\u2009=\u20090.044] and 0.84 [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001] respectively), but they were all significantly better than SAP (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.028 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010resolution microperimetry enabled improved performance for detecting glaucomatous damage compared to SAP, highlighting the potential value of fundus\u2010tracking and higher\u2010resolution sampling for the detection of glaucomatous visual field loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ceo.14528","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T19:26:54Z","timestamp":1743017214000},"page":"602-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance"],"prefix":"10.1111","volume":"53","author":[{"given":"Marc G.","family":"Sarossy","sequence":"first","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  East Melbourne Victoria Australia"},{"name":"Ophthalmology, Department of Surgery The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Rezk","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital  East Melbourne Victoria 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