{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:06:45Z","timestamp":1787162805151,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012990","name":"Universit\u00e0 degli Studi di Siena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The study objective was to compare the effectiveness of adalimumab (ADA) in monotherapy and in combination with methotrexate (MTX) for paediatric noninfectious uveitis (NIU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Registry\u2010based observational study. Children receiving ADA for active uveitis were divided into the ADA monotherapy group (group 1) and the ADA plus MTX combination group (group 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty four children were enrolled (146 eyes): 22 in group 1 (26.2%) and 62 in group 2 (73.8%). ADA effectiveness was complete in 48 children (57.1%), partial in 23 (27.4%) and absent in 4 (5.3%), without any differences across the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.89). Fewer relapses per 100 PY occurred after ADA treatment both in group 1 (280.0 vs. 23.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and in group 2 (297.9 vs. 86.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The final BCVA was similar between groups 1 and 2 [median 1.0 (IQR 0.3) and 1.0 (IQR 0.3), respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55]. A statistically significant steroid\u2010sparing effect was observed in the entire cohort and in group 2 at the 6\u2010month (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), 12\u2010month (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and last follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045). The estimated ADA retention rate was 97.1% at 12\u2009months, 87.7% at 24\u2009months, and 82.6% at 36\u2009months, without a statistically significant difference among the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADA monotherapy could be equally effective as its combination with MTX in both preventing uveitis relapses and preserving visual acuity in paediatric NIU, with comparable retention rates over 36\u2009months of treatment. The steroid\u2010sparing effect of ADA monotherapy warrants further extensive evaluation to define its optimal placement in the therapeutic strategy for paediatric NIU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14534","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T07:42:53Z","timestamp":1743838973000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adalimumab Monotherapy or Combination Therapy With Methotrexate in Paediatric Uveitis: Data From the\n                    <scp>AIDA<\/scp>\n                    Network Uveitis Registry"],"prefix":"10.1111","volume":"53","author":[{"given":"Carla","family":"Gaggiano","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medical Sciences, Surgery and Neuroscience University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center]  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0684-1989","authenticated-orcid":false,"given":"Alejandra","family":"de\u2010la\u2010Torre","sequence":"additional","affiliation":[{"name":"Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Guerriero","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otolaryngology University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Costi","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Rheumatology, Azienda Socio\u2010Sanitaria Territoriale (ASST) Gaetano Pini\u2010Centro Specialistico Ortopedico Traumatologico (CTO)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaafar","family":"Ragab","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine Cairo University  Giza Egypt"},{"name":"Faculty of Medicine Newgiza University (NGU)  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Paroli","sequence":"additional","affiliation":[{"name":"Uveitis Unit, Department of Sense Organs, Eye Clinic Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Pediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences Sapienza University of Rome, Polo Pontino  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Breda","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit S.S. 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