{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:46Z","timestamp":1787014006243,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["07180256"],"award-info":[{"award-number":["07180256"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Exper Ophthalmology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate single\u2010nucleotide polymorphisms (SNPs) reported in the largest up\u2010to\u2010date systematic review and meta\u2010analysis on primary angle\u2010closure disease (PACD), on their associations with primary angle\u2010closure glaucoma (PACG) and disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study involved a case\u2013control design for PACG risk and a case\u2010only design for PACG progression risk, including 628 PACG patients and 564 controls for disease association and 386 PACG patients with up to 10\u2010year follow\u2010up for PACG progression analysis. Associations of 17 SNPs in 15 genes with PACG were analysed using logistic regression. Sex\u2010stratified association analysis was performed, followed by the Breslow\u2010Day test. Genetic risk for PACG progression was evaluated using logistic regression. Bonferroni correction of\n                      <jats:italic>p<\/jats:italic>\n                      values was adopted for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LOXL1 rs3825942 (G153D;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0026; OR\u2009=\u20090.65) was significantly associated with PACG, while ABCC5 rs1401999 showed a nominal association (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023; OR\u2009=\u20091.32). ABCA1 rs2422493 was significantly associated with PACG in females (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0016; OR\u2009=\u20090.70) but not in males (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.95; OR\u2009=\u20090.99); and the Breslow\u2010Day Test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) suggested a sex\u2010specific association in females.\n                      <jats:italic>VAV3<\/jats:italic>\n                      rs6689476 showed nominal associations with PACG progression at 3\u2010year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045; OR\u2009=\u20092.86), 5\u2010year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037; OR\u2009=\u20092.84) and 10\u2010year follow\u2010ups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03; OR\u2009=\u20092.74), but the\n                      <jats:italic>p<\/jats:italic>\n                      values could not withstand Bonferroni correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrated a role of LOXL1 in PACG and a sex\u2010specific effect of ABCA1 in the Hong Kong Chinese population while suggesting a potential role of\n                      <jats:italic>VAV3<\/jats:italic>\n                      in PACG progression, which has yet to be further confirmed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ceo.14539","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T20:59:11Z","timestamp":1744750751000},"page":"660-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Association of Primary Angle\u2010Closure Glaucoma and Disease Progression"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4962-9558","authenticated-orcid":false,"given":"Yu Jing","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poemen P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Hong Kong Eye Hospital  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-1486","authenticated-orcid":false,"given":"Jason C.","family":"Yam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Hong Kong Eye Hospital  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Pui","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement C.","family":"Tham","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Hong Kong Eye Hospital  Hong Kong (SAR) China"},{"name":"Department of Ophthalmology and Visual Sciences Prince of Wales Hospital  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-5840","authenticated-orcid":false,"given":"Li Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Lam Kin Chung. Jet King\u2010Shing Ho Glaucoma Treatment and Research Centre The Chinese University of Hong Kong  Hong Kong (SAR) China"},{"name":"Hong Kong Eye Hospital  Hong Kong (SAR) China"},{"name":"Department of Ophthalmology and Visual Sciences Prince of Wales Hospital  Hong Kong (SAR) China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.624179"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.124"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2390"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3540"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2024.0363"},{"issue":"10","key":"e_1_2_7_10_1","article-title":"Genetic Markers PLEKHA7, ABCC5, and KALRN Are Not Associated With the Progression of Primary Angle Closure Glaucoma (PACG) in Malays","volume":"13","author":"Thangavelu L.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000002103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22304"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17245"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.238"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.10.021"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.07.027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.12.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.07.044"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13744"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.4.19"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102019\u2010315746"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjo.2023.100003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100562"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250772"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3226"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-021-10131-1"},{"issue":"1","key":"e_1_2_7_28_1","first-page":"18","article-title":"Gender Specific Association of ABCA1 Gene R219K Variant in Coronary Disease Risk Through Interactions With Serum Triglyceride Elevation in Turkish Adults","volume":"14","author":"\u00c7oban N.","year":"2014","journal-title":"Anadolu Kardiyoloji Dergisi"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427\u2010021\u20102126\u20102"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab614"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3078"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1992.tb02152.x"}],"container-title":["Clinical &amp; Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ceo.14539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:48:20Z","timestamp":1754473700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ceo.14539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/ceo.14539"],"URL":"https:\/\/doi.org\/10.1111\/ceo.14539","archive":["Portico"],"relation":{},"ISSN":["1442-6404","1442-9071"],"issn-type":[{"value":"1442-6404","type":"print"},{"value":"1442-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"2024-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}